新生儿缺血缺氧性脑病对早产儿排尿方式的影响

A study on voiding pattern in preterm newborns with hypoxic-ischemic encephalopathy

目的 探讨新生儿缺血缺氧性脑病（HIE）对早产儿排尿方式的影响。方法选取出生后4～15d确诊为新生儿缺血缺氧性脑病早产儿48例，男34例，女14例，孕（32．1±0．7）周，出生时体重（2．5±0．3）kg。选取同期出生后4～15d无缺血缺氧性脑病的33例早产儿为对照组，男22例，女11例，孕（32．3±1．4）周，出生时体重（2．4±0．5）kg。记录4h（早上8点～10点）排尿情况，包括排尿量、残余尿量、排尿次数等参数，同时记录饮奶量、液体输入量及摄入时间，液体摄入量按标准进行。结果共记录了248次排尿，其中HIE组136次，对照组112次。HIE组排尿量和排空比例分别为（14．8±8．3）ml和11．6oA，均显著小于对照组[（16．5±9．2）ml和24．3％]；而HIE组的排尿次数、平均残余尿量分别为（2．8±1．1）次、（1．5±1．3）ml，对照组为（3．3±1．2）次、（1．7±0．9）ml，两者之间的差异无统计学意义。结论缺血缺氧性脑病可使早产儿出现一定程度排空和储尿障碍，表现为每次排尿量及排空比例降低。

Objective To investigate the poxic-ischemic encephalopathy （HIE）. Methods voiding pattern in preterm neonates affected by hy- A total of 81 preterm newborns aged 4 to 15 days at The First Affiliated Hospital of Zhengzhou University from March to October 2010 were included in this study,48 of them affected by HIE （32.1 ±0. 7 weeks of gestation） with weight of 2. 5 ± 0. 3 kg, the other 33 preterm were normal （32. 3± l. 4） weeks of gestation,body weight： 2. 4 ± 0. 5 kg）. The voided volume,post void residual （PVR） volume, voiding frequency per 4 hours as well as the quantity of milk and liquid intake within the same time schedule for 4 hours from 8AM to 2AM were recorded. The liquid intake was given according to standard protocol. Results A total of 248 times of voiding were recorded. Voided volume and bladder empty percentage was significant lower in newborn with HIE comparing to controls [ （14. 4 ± 8. 3） ml vs. （ 16. 5± 9.2） ml and 11.6 % vs. 24. 3 %, （P〈0.05）, respectively, whereas voiding frequency, PVR volume showed no significant difference. Conclusions The difference of voiding patterns between newborn with HIE and controls indicates HIE has a significant effect on the bladder storage and voiding function.