中国正常成人中脑体积的高分辨力MRI的测量与分析

Measuring and analyzing the volume of midbrain in healthy Chinese adults

目的测量中国健康汉族成人中脑体积,并建立正常值参考范围,分析中脑体积与年龄及性别的关系,为建立中国正常人标准脑提供基础数据。方法选取18~70岁健康成年志愿者1000名,按年龄18~30、31~40、41~50、51~60、6l^70分为共5组,标记为A、B、C、D、E,每组共计200名,男、女各100名。对所有受试者行全脑容积MR扫描,用3D体积分析软件进行中脑体积测量。分析年龄与中脑体积的相关性。结果男性中脑平均体积[(8087.89±1177.43)mm3]大于女性[(7763.87±1007.44)mm3,t=-4.68,P<0.001]。男性A^E组中脑体积分别为(8857.65±980.12)mm3、(8691.22±913.56)mm3、(8072.26±1024.78)mm3、(7688.33±981.91)mm3、(7129.98±1059.98)mm3,女性A^E组中脑体积分别为(8290.68±995.41)mm3、(8034.79±1000.00)mm3、(7767.43±907.28)mm3、(7619.18±836.72)mm3、(7107.29±889.09)mm3。A^C组男性中脑体积均大于女性(P均<0.05),D、E组男、女差异则无统计学意义。男性除A组与B组外,其余各组间差异均有统计学意义(P均<0.05);女性除A组与B组、C组与D组外,其余各组间差异均有统计学意义(P均<0.05)。男性和女性中脑体积均与年龄相关(r=-0.55、-0.38,P均<0.001)。结论正常中国成人中脑体积存在性别差异,男性中脑体积总体上大于女性;18~50岁男性中脑体积大于女性,51~70岁男女间无显著差异。中脑体积及其性别间差异均随年龄增大而减小。

Objective To measure the volume of midbrain in healthy Chinese adults of Han nationality,and to explore the relation ship between midbrain volumes and age and sex,in order to provide morphological data for the construction of database of standard digital brain of Chinese people.Methods Totally 1000 healthy volunteers were recruited and divided into 5 groups（group A—E） according to age： 18—30,31—40,41—50,51—60,61—70 year-old.Each group included 200 volunteers with 100 male and 100 female.All the subjects underwent three-dimensional MR scan,and whole brain volume was obtained with 3D volume analysis software.Correlation of age with midbrain volumes were analyzed statistically.Results The midbrain volume of male and female was（8087.89±1177.43）mm3 and（7763.87±1007.44）mm3,respectively（t=-4.68,P0.001）.The midbrain volumes in the five groups were（8857.65±980.12）mm3,（8691.22±913.56）mm3,（8072.26±1024.78）mm3,（7688.33±981.91）mm3,（7129.98±1059.98）mm3 in male and（8290.68±995.41）mm3,（8034.79±1000.00）mm3,（7767.43±907.28）mm3,（7619.18±836.72）mm3 and（7107.29±889.09）mm3 in female.Midbrain volumes in group A—C in male were larger than those in female（all P0.05）,while there was no difference between male and female in the group D and E.Each group was different from others significantly（all P0.05）,besides group A and B in male and group A and B,group C and D in female.Midbrain volumes in female and male were all correlated with ages（r=-0.55,-0.38,both P0.001）.Conclusion In general,volume of midbrain is different in male and female adults.The volume of midbrain in male is larger than that in female in 18—50 years old,while no differences is found between the two sexes in 51—70 years old.The midbrain volumes and the difference between two sexes decrease with the increase of age.