摘要
目的探讨肿胀性红斑狼疮的临床与病理特点,提高对本病的认识。方法对2008-2010年确诊的4例肿胀性红斑狼疮的临床资料进行总结。结果4例均具有肿胀性红斑狼疮的表现,在面部曝光部位发生肿胀性红斑,有光敏并日晒后加重。红斑狼疮免疫学指标多为阴性。组织病理检查:真皮网状层黏蛋白沉积,阿新蓝染色阳性。4例均应用羟氯喹200mg,每日2次口服治疗。用药6个月至1年,有明显疗效,正在随访中。结论肿胀性红斑狼疮是慢性皮肤型红斑狼疮的一个亚型,提高对肿胀性红斑狼疮的认识,有助于减少误诊,及时治疗。
Objective To investigate the clinical and pathological characteristics of lupus erythematosus tumidus (LET), and to improve the understanding of LET. Methods Clinical data on 4 cases of LET collected from 2008 to 2010 were retrospectively reviewed. Results All of the 4 patients had characteristic clinical presentation (tumefy erythema) at sun exposed areas with photosensitivity, which could be exacerbated by sun exposure. Most of immunological parameters of lupus erythematosus were negative in these patients. Histopathological examination revealed mucin deposition in the reticular layer of dermis and Alcian blue staining was positive. Marked improvement was achieved in all of the patients after 6 to 12 months of treatment with oral hydroxychloroquine 200 mg twice daily. Follow up of the patients was underway. Conclusions LET is a subtype of chronic cutaneous lupus erythematosus. To strengthen the knowledge of LET may contribute to the diagnosis and treatment of this entity.
出处
《国际皮肤性病学杂志》
2012年第1期1-3,共3页
International Journal of Dermatology and Venereology
关键词
红斑狼疮
肿胀性
诊断
治疗
Lupus erythematosus, tumidus
Diagnosis
Therapy