光动力疗法治疗细菌感染性皮肤病研究进展

Photodynamic therapy in the treatment of bacterial skin infection： an update

光动力疗法是一种非侵入性治疗手段，通过光敏剂选择性聚集于靶细胞，并被相应波长光源激发，产生单线态氧和自由基等细胞毒素从而对靶细胞产生选择性杀伤作用。在近20年的皮肤科临床应用中，该技术愈加成熟与完善，不但用于治疗增生性疾病还涉及多种皮肤病的治疗，尤其是在一些细菌感染性皮肤病方面表现出较好的临床疗效。概述近年来与光动力疗法治疗细菌感染性皮肤病相关的体外实验、动物实验及临床应用的研究。

Photodynamic therapy is a new type of non-invasive treatment, which can selectively kill target cells by toxins such as singlet oxygen and free radicals produced after selective accumulation of photosensitizers in target cells and irradiation with defined wave-length light. In the past nearly 20 years of clinical application in dermatology, the technique has become increasingly mature and improved. It has been used not only in the treatment of proliferative diseases, but also in various skin diseases. Particularly, it has shown potential efficacy in the treatment of some bacterial skin infections. This paper outlines the advances in photodynamic therapy for the treatment of bacterial skin infections from multiple aspects, including animal studies, in vitro trials and clinical application.