玫瑰糠疹的研究进展

Some progress in pityriasis rosea

一些病毒包括HHV-6、HHV-7、HHV-8、甲型H1N1流感病毒以及很多种药物与部分玫瑰糠疹发病有关，T淋巴细胞介导的细胞免疫在玫瑰糠疹的发生、发展中起重要的作用，HLA—DQB1＊04可能参与玫瑰糠疹发病的遗传易感性。部分玫瑰糠疹临床表现不典型，皮疹形态、大小、分布、部位、数量及病程等与典型玫瑰糠疹不同。妊娠期的玫瑰糠疹患者早产、流产的发生率较高。药物诱导所致的玫瑰糠疹病情相对较重。目前尚无特异性疗法，阿昔洛韦、UVB、UVA1在部分玫瑰糠疹的治疗中显示较好的临床疗效。

Recent studies have found that some viruses, including human herpesvirus （HHV）-6, HHV-7, HHV-8, influenza A （H1N1） virus, as well as a variety of drugs are involved in the pathogenesis of PR. The cell immunity mediated by T lymphocytes plays an important role in the development of pityriasis rosea （PR）. In addition, HLA-DQBI＊04 allele may be associated with the genetic susceptibility to PR. Some patients with PR may show atypical manifestations in rash shape, size, distribution, location, number and duration. Pregnant women with PR have a higher incidence of premature birth and abortion. Drug-induced PR appears more severe than classical type of PR. There is no specific therapy for PR. Acyclovir, ultraviolet B （UVB） and UVA1 have shown attractive efficacy in the clinical treatment of some types of PR.