人乳头瘤病毒感染的预防和治疗进展

Progress in the treatment of human papillomavirus infection

人乳头瘤病毒是一种环状双链DNA病毒。部分亚型可特异性地感染肛门生殖器皮肤和黏膜，导致生殖器疣和鳞状上皮内皮损等良恶性病变。宫颈持续的高危型人乳头瘤病毒感染是宫颈癌发生的必要条件。目前可用于治疗人乳头瘤病毒感染的方法主要有预防性疫苗、杀微生物剂、局部免疫调节剂、治疗性疫苗等。概述近年来针对人乳头瘤病毒的治疗进展。

Human papillomavirus （HPV） is a double-stranded DNA virus. Some HPV subtypes can specifically infect the skin and mucous membranes of the anogenital region, and induce a spectrum of epithelial proliferative diseases ranging from benign warts to intraepithelial neoplasms. It is now recognized that persistent cervical infection with high risk HPV subtypes is a prerequisite for the occurrence of cervical cancer. The treatment of HPV infection mainly includes prophylactic vaccines, microbicides, topical immunomodulators, therapeutic vaccines, etc. This paper presents recent progress in the treatment of HPV infection.