β-防御素在银屑病发病机制中的作用

Beta-defensins in the pathogenesis of psoriasis

β-防御素是一组小分子抗菌肽，能够抗多种病原微生物感染，促进炎症反应，并对T细胞等发挥趋化作用。研究发现，银屑病发病可能与β-防御素有关。β-防御素可活化银屑病免疫相关的炎症因子，趋化未成熟的树突细胞和记忆T细胞，并通过促分裂素原活化蛋白激酶作用于角质形成细胞产生炎症因子，将固有性免疫和获得性免疫连接起来。未来应深入探讨β-防御素在银屑病发病中的作用，进一步完善银屑病的免疫学发病机制，寻求治疗新靶点。

Beta-defensins are a group of small-molecule antibacterial peptides, which can resist infection with various pathogenic microorganisms, promote inflammation, and act as chemoattraetants for T cells. Beta-defensins are speculated to be associated with the pathogenesis of psoriasis. They can attract immature dendritic cells and memory T cells, activate immunity-related inflammatory factors involved in psoriasis, and connect the innate and adaptive immunity via inflammatory cytokines produced by keratinocytes after stimulation by mitogen-activated protein kinases. It is warranted to assess the effects of beta-defensins in the pathogenesis of, clarify the immunological pathogenesis of, and to seek new therapeutic targets in the future for, psoriasis.