摘要
白介素18是由单核细胞、巨噬细胞等多种细胞产生的一种具有多功能和多效应的前炎性因子，是固有和适应性免疫之间的一种重要联系，是细胞及体液免疫的调节物。通过激活多个信号转导途径、诱导干扰素γ的产生、调节免疫细胞功能参与机体免疫，其作用也体现在支持不同的Th细胞亚型的分化，促进Th1和Th2两型免疫应答。研究显示，白介素18在某些炎症、自身免疫性疾病和肿瘤中表达异常，提示白介素18与这些疾病的发生有一定的相关性。
Interleukin-18 （IL-18） is a multi-functional and pleiotropic proinflammatory cytokine produced by various types of cells such as monocytes and macrophages. It acts as a critical link between innate and adaptive immune responses and is also an important modulator of cellular and humoral immunity. It takes part in immune responses by activating multiple signal transduction pathways, stimulating the production of interferon （IFN）-% and regulating the functions of immunocytes. IL-18 also promotes the differentiation of various T helper cell subsets as well as immune responses mediated by Thl and Th2 lymphocytes. Studies have shown an abnormal expression of IL-18 in some inflammatory, autoimmune diseases and tumors, indicating a certain association of IL-18 with these entities.
出处
《国际皮肤性病学杂志》
2012年第1期39-42,共4页
International Journal of Dermatology and Venereology
