450株铜绿假单胞菌的临床分布及药敏分析

450 Strains Aeruginosa Clinical Distribution and Drug Susceptibility

目的研究本地区铜绿假单胞菌感染的临床分布及药敏情况,指导临床抗生素的使用。方法对细菌进行常规分离培养鉴定,并进行药敏实验。结果 450株铜绿假单胞菌临床主要分布情况:痰68.1%、伤口脓液13.1%、尿液6.0%,以呼吸道感染为主;抗生素耐药情况:头孢哌酮/舒巴坦、阿米卡星、亚胺培南的耐药率分别达到21.8%、28.3%、29.9%,头孢吡肟、头胞他啶、哌拉西林/他唑巴坦、环丙沙星的耐药率分别33.7%、34.4%、36.9%、38.6%,其余的抗生素耐药性更高,且呈现多重耐药性。结论临床用药应根据药敏分析,合理使用抗生素。

Objective To study the region of Pseudomonas aeruginosa infection in the clinical distribution and drug sensitivity,guide clinical use of antibiotics.Methods Bacterial conventional isolation,identification,and drug susceptibility test.Results 450 strains of Pseudomonas aeruginosa clinical main distribution： sputum 68.1%,wound pus13.1%,urine 6%,mainly respiratory infections;antibiotic resistance： Cefoperazone/Sulbactam,Amikacin,Imipenem resistance rate were 21.8%,28.3%,29.9%,Cefepime,Ceftazidime,Piperacillin/tazobactam,Ciprofloxacin resistance rates were 33.7%,34.4%,36.9%,38.6%,the rest of the antibiotic resistance higher,and present multiple antibiotic resistance.Conclusion Clinical medication should be based on the sensitivity analysis,the rational use of antibiotics.