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KLF14基因rs972283多态性与2型糖尿病的关系研究 被引量：1

Relationship between polymorphism of KLF14 rs972283 and type 2 diabetes in Ningxia
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摘要 目的研究KLF14基因rs972283多态性与宁夏2型糖尿病的关系。方法用聚合酶链反应-限制性片段长度多态性的方法(RFLP-PCR),对宁夏2型糖尿病患者(DM组)和正常对照组(NC组)KLF14基因rs972283位点进行基因多态性和等位基因频率分析,测定相应生化指标。结果 KLF14基因rs972283位点多态性在DM组和NC组的分布差异无统计学意义(P>0.05);DM组内携G等位基因患者的体质指数(BMI)、腰臀比(WHR)、血胆固醇(TC)、胰岛素抵抗指数(HOMA-IR)均高于携A等位基因者,DM组内携G等位基因者胰岛β细胞功能(HOME-β)较携A等位基因者低,差异均有统计学意义(P<0.05)。结论 KLF14基因rs972283位点多态性可能与宁夏2型糖尿病发病无关,与肥胖、血脂代谢等有关。 Objective To investigate the relationship between polymorphism of KLF14 rs972283 and type 2 diabetes mellitus （T2DM） in Ningxia. Methods Polymerase chain reaction - restriction fragment length polymorphism （ PCR - RFLP） and case - control was used to analyze the KLF14 rs972283 and measure the clinical parameters in T2DM and the controls. Results There were no significant differences in genotypic and allelic frequ- encies of the KLF14 rs972283 polymorphism in T2DM and controls. The BMI, WHR, TC and HOMA - IR in patients with G allele of T2DM were significantly higher than those in the controls. The HOMA - 13in patients with G allele of T2DM were significantly lower than those in the control （ P 〈 0. 05 ）. Conclusion The polymorphism of KLF14 rs972283 may have no relation with T2DM in Ningxia, but it may have relation with obesity and lipids metabolism.
作者 史静 强丹 谢晓敏 李仁达 张丽 周海燕 于丽萍 李玲 邹晓燕 牛旭东 杨泽
机构地区 宁夏银川市第一人民医院 国家卫生部北京医院老年医学研究所
出处 《宁夏医学杂志》 CAS 2011年第12期1151-1153,1140,共3页 Ningxia Medical Journal
基金 宁夏自然科学基金项目(NZ08145)
关键词 2型糖尿病 KLF14基因 多态性 Type 2 diabetes mellitus KLF14 gene Polymorphism
分类号 R587.1 [医药卫生—内分泌]
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参考文献8

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共引文献5

同被引文献46

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宁夏医学杂志
2011年 第12期

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