2型糖尿病左室舒张功能及颈动脉损害的相关研究

Study on the Correlation Between Left Ventricle Diastolic Function and Carotid Artery Damage in Patients with Type 2 Diabetes Mellitus

[目的]探讨2型糖尿病（T2DM）对左室舒张功能及颈动脉损害的影响.[方法]随机选取T2DM患者136例（T2DM组）,健康对照组90例,均采用标准方法检测血压、测量身高（m）、体重（kg）;检测血糖、血脂等生化指标.采用标准方法测定E峰与A峰比值（E/A）,并测量颈动脉内膜中层厚度（IMT）.[结果]T2DM组E峰值及E/A比值显著低于对照组,[（53.43±12.78） cm/s VS （72.82±14.73） cm/s;（0.76±0.32） VS （1.24±0.39）]（P〈0.05）,IMT显著高于对照组[（0.89±0.25）mm VS （0.53±0.18）mm]（P〈0.05）,颈动脉斑块发生率、斑块积分高于对照组,差异有统计学意义（P〈0.05）.以E/A比值为因变量,自变量包括年龄、BMI、TG、TC、FPG、2hPG、HOMA-IR、LDL.年龄、2hPG,HOMA-IR为心室舒张功能的独立危险因素（β值分别为0.187、0.005、0.172,P值分别为0.034、0.043、0.012）.[结论]糖尿病患者更易发生左室舒张功能及颈动脉损害.

[Objective] To explore the effect of type 2 diabetes mellitus on left ventricle diastolic function and carotid artery damage. [Methods]Totally 136 patients with type 2 diabetes mellitus（DM group） and 90 healthy subjects were selected randomly. Blood pressure, height, weight, blood glucose, lipids, the ratio of E peak to A peak（E/A） and carotid intima-media thickness（IMT） of all subjects were measured by using standard method. [Results] The E peak and E/A ratio in DM group were lower than those in control group[（53.43 ±12.78）cm/s vs （72.82±14.73）cm/s, （0.76±0.32）cm/svs （1.24±0.39）cm/s]（P〈0.05）. IMTinDM group was higher than that in control group [（0.89±0.25）mm vs （0. 53±0.18）mini（ P 〈0.05）. The incidence of carotid atherosclerotic plaque and plaque score in DM group were higher than those in control group, and there were significant differences between two groups（ P 〈0.05）. The ratio of E/A was the dependent variable, and the age, BMI, TG, TC, FPG, 2hPG, HOMA-IR and LDL were the independent variables. The age, 2hPG and HOMA-IR were the independent risk factors of left ventricle diastolic function（β= 0. 187, 0. 005,0. 172, P =0. 034,0. 043, 0. 012）. [Conclusion] The patients with diabetes mellitus are apt to have the damage of left ventricle diastolic function and carotid artery.