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心脏T型钙离子通道 被引量：2

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摘要 心肌细胞膜存在两种不同的Ca2＋通道（L型和T型）。1953年Fatt和Katz首次发现电压依赖性Ca2＋内流这种重要生理特征,1975年Hagiwara等人经研究又进一步证实。心脏电压依赖性Ca2＋通道被认为与细胞膜去极化过程中调控Ca2＋内流和参与细胞的兴奋、收缩、激素分泌及相关基因转录相关。20世纪80年代,在心肌细胞中第一次记录到两种不同的Ca^2＋通道：L型和T型Ca^2＋通道。
作者 Erlinda The Muktanand Vikash Jhummon 魏毅东
机构地区 同济大学附属第十人民医院心内科
出处 《中国循证心血管医学杂志》 2011年第5期393-397,共5页 Chinese Journal of Evidence-Based Cardiovascular Medicine
基金 国家自然科学基金资助项目(30800466)
关键词 T型Ca^2+通道 钙离子通道 心脏 心肌细胞膜 电压依赖性 CA2+ 相关基因转录 生理特征
分类号 Q735 [生物学—分子生物学]
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参考文献54

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同被引文献34

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  • 8Koppaka V,Thompson DC,Chen Y,et al. Aldehyde dehydrogenase inhihitors: a comprehensive review of the pharmacology., mechanism of action, substrate specificity, and clinical application[J]. Pharmacol Rev, 2012, 64(3):520-39.
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中国循证心血管医学杂志
2011年 第5期

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