人脑胶质瘤血管生成与基质细胞衍生因子-1α表达的相关性

Correlation of human glioma angiogenesis with stromal cell derived factor-1α expression

目的:探讨基质细胞衍生因子-1α(stromal cell derived factor-1α,SDF-1α)在人脑胶质瘤中的表达及其与胶质瘤血管生成的相关性。方法:以58例人脑胶质瘤及18例正常脑组织为研究对象,应用免疫组织化学方法检测SDF-1α及CD105的表达情况,并计数CD105标记的微血管密度(microvessel density,MVD)。结果:正常脑组织中未见SDF-1α表达。SDF-1α标记指数及CD105-MVD与胶质瘤病理分级密切相关(P<0.01),SDF-1α标记指数与CD105-MVD均呈正相关(r=0.872,P<0.01)。SDF-1α表达和CD105-MVD与患者的年龄、性别及瘤体大小无明显相关性(P>0.05)。结论:SDF-1α和CD105-MVD可作为反映胶质瘤恶性程度的指标;SDF-1α在胶质瘤中表达增加可能引起胶质瘤的发生、发展;SDF-1α可能通过促进血管内皮细胞向肿瘤迁移,从而刺激肿瘤血管的生成。

Objective To explore the expression of stromal cell derived factor-1α（SDF-1α） in human glioma and its relationship with glioma angiogenesis. Methods Altogether 58 cases of gliomas and 18 normal brain tissues were selected for our study.The expressions of SDF-1α and CD105 were detected by immunohistochemistry,and CD105 marked microvessel density（MVD） was counted. Results Expression of SDF-1α was not found in normal brain tissues.SDF-1α marked index and CD105-MVD were closely related to the grade of glioma（P0.01）.SDF-1α marked index was positively correlated with CD105-MVD（r=0.872,P0.01）.SDF-1α expression and CD105-MVD were negatively correlated with patients＇ age,gender,and the tumor size（P0.05）. Conclusion SDF-1α and CD105-MVD could serve as indexes for malignant degree of glioma.Increased expression of SDF-1α in glioma may lead to the pathogenesis and development glioma.SDF-1α may induce the tumor vessel formation by promoting the migration of vascular endothelial cells to tumor.