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糖尿病肾病与线粒体氧化应激 被引量：15

Mitochondria-induced oxidative stress and diabetic nephropathy
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摘要 近年来的研究发现,氧化应激与糖尿病肾病的发生、发展有着密切联系。线粒体电子传递呼吸链氧自由基产生过多是高糖介导组织损伤主要原因之一,改善线粒体氧化应激状态成为防治糖尿病肾病新的研究方向。 Recent studies demonstrate that oxidative stress plays a significant role in the pathogenesis of diabetic nephropathy.Excessive oxygen free radical from mitochondrial respiratory chain is a major reason for tissue damage induced by high glucose.How to control mitochondrial oxidative stress in diabetic nephropathy is a new research direction.
作者 张苏皖 李素梅
机构地区 安徽医科大学附属省立医院内分泌科
出处 《国际病理科学与临床杂志》 CAS 2011年第6期535-538,共4页 Journal of International Pathology and Clinical Medicine
关键词 糖尿病肾病 线粒体氧化应激 活性氧 diabetic nephropathy mitochondria-induced oxidative stress reactive oxygen species
分类号 R587.2 [医药卫生—内分泌]
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参考文献28

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  • 2Satoh M, Fujimoto S, Haruna Y, et al. NAD (P) H oxidase and uncoup led nitric oxide synthase are major sources of glomerular su- peroxide in rats with experimental diabetic nephropathy[J]. Am J Physiol, 2005,288 (6): F1144-1452.
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  • 8Susztak K, Raft AC, Schiffer M, et al. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy [J]. Diabetes,2006,55 ( 1 ) : 225-233.
  • 9Lee EA, Seo JY, Jiang z, et al. Reactive oxygen species mediate high glucose induced plasminogen activator inhibitor-1 up-regula- tion in mesangial cells and in diabetic kidney [J ]. Kidney Int, 2005,67 (5) : 1762-1771.
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国际病理科学与临床杂志
2011年 第6期

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