急性呼吸窘迫综合征的药物治疗

Pharmacotherapy of acute respiratory distress syndrome

急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)的防治是多途径、综合性的救治过程。目前尚无治疗急性肺损伤(acute lung injury,ALI)/ARDS的特效药物,对其有缓解作用的药物主要针对其的急性渗出期、炎症反应或氧化损伤以及纤维增生期。联合多种药理因素的机械协同作用或者叠加作用以及药物与非药物干预(如机械通气)的治疗可同时作用于ARDS病理生理的多方面,对该病的防治起着至关重要的作用。

Current therapy for acute respiratory distress syndrome mainly emphasizes multi-channel and comprehensive treatments,such as mechanical ventilation,optimal fluid management,and standard treatment for the initial disease.Pharmacotherapy for acute respiratory distress syndrome is under intensive study.It includes treating acute exudative phase,fibroproliferative phase,and inflammation or oxidant injury with different drugs.Development of optimal medicinal chemical agents and combination therapy strategies for ALI/ARDS play an important role in treating this disease.