含左氧氟沙星序贯疗法根除幽门螺杆菌感染58例疗效观察

Eradication of helicobacter pylori infection with levofloxacin sequential therapy of 58 cases

目的观察兰索拉唑、左氧氟沙星、阿莫西林、克拉霉素组成的10 d序贯疗法根除幽门螺杆菌(HP)的疗效。方法将经胃镜检查确诊为各种慢性胃炎或消化性溃疡同时HP阳性的患者114例,随机分为两组,治疗组(58例)方案为前3 d给予兰索拉唑、阿莫西林、克拉霉素,后7d给予兰索拉唑、左氧氟沙星、阿莫西林;对照组(56例)三联为兰索拉唑、阿莫西林、克拉霉素,疗程10 d,比较治疗后两组患者HP根除率。结果治疗组HP根除率91.3%,对照组为73%,其根除率两组差异有统计学意义(P<0.05)。结论以兰索拉唑、左氧氟沙星等组成的10 d序贯疗法治疗HP具有较高的根除率。

Objective To evaluate the eradication rate of ten day＇s sequential therapy consisted of lansoprazole, amoxicillin, levofioxacin and clarithromycin for helicobacter pylori （HP） infection. Methods Totally 114 HP-infected patients with peptic ulcer or chronic gastritis diagnosed by gastroscopy were enrolled. These patients were randomly divided into trial group （n=58） and control group （n=56）. Patients in trial group received lansoprazole, amoxieillin, clarithromycin for the first 3 days, and followed by lansoprazole, levofloxacin and amoxicillin for the last 7 days, and patients in control group received lansoprazole, clarithromycin and amoxicillin for 10 days. The status of HP in patients of these two groups was compared after completion of treatment. Results The eradication rate of sequential therapy for ten days was 91.3% and that of control group was 73%. There was significant difference between these two groups （P〈0.05）. Conclusion The lO-day sequential therapy comprising lansoprazole and levofloxacin can achieve a higher eradication rate of HP.