木薯淀粉微球的制备

Preparation and drug loading properties of cassava starch microspheres

以木薯淀粉为材料,N,N′-亚甲基双丙烯酰胺(MBAA)为交联剂采用反向乳化法制备木薯淀粉微球。研究了交联剂、引发剂等因素对载药量的影响,得到了最佳的制备工艺条件。采用扫描电镜(SEM)、红外光谱(IR)、XRD等对所制备的木薯淀粉微球进行了表征。结果表明制备的木薯淀粉微球呈表面粗糙的圆球形,大小为10μm,载药量增加明显并且有很好的缓释作用。

The cassava starch micro-spheres were prepared in a W/O reverse emulsion via grafting and cross-linking polymerization in presence of cross-linker N, N-methylene-bis-acrylamide. The optimum parameters were obtained though research the relation- ship between drug-loading rate and dosage of crosslinking agent, dosage of initiator and so on. The preparation was characterized through these methods： infrared spectroscopy（IR）, scanning electron microscopy（SEM） and so on. The results show that cassava starch micro-spheres are spherical particulates with rough surface and measuring 10 um size, It has increased obviously drug- loading rate and sustained release.