含噻唑烷二酮-3-乙酸结构查尔酮衍生物的合成及抗菌活性的研究

Synthesis and Anti-bacterial Activity of Novel Chalcone Derivatives Containing 2,4-Thiazolidinedione-3-acetic Acid Moiety

合成了一系列含噻唑烷二酮-3-乙酸结构的新型查尔酮衍生物,并对化合物进行了抗菌活性测定.结果显示,一些化合物对4种多重耐药菌显示出较强的抗菌活性,其中化合物8g,8i,8l和8m在抗耐甲氧西林金黄色葡萄球菌的最小抑制浓度(MIC)达到4μg/mL,与对照药诺氟沙星(norfloxacin)相当.另外,在64μg/mL浓度下,所有化合物对大肠杆菌1356均无明显抑制活性.

A series of novel chalcone derivatives bearing the 2,4-thiazolidinedione-3-acetic acid moieties（8a～8p） were synthesized,and evaluated for their anti-bacterial activity.The results demonstrated that some compounds presented good antimicrobial activities against four multidrug-resistant clinical isolates,among which compounds 8g,8i,8l and 8m with minimum inhibitory concentration（MIC） value of 4 μg/mL showed as active as the standard drug,norfloxacin,against methi-cillin-resistant S.aureus.None of the compounds exhibited obvious activity against the Gram-negative bacteria E.coli 1356 at 64 μg/mL.