肺癌肝转移24例介入治疗临床分析

Interventional treatment of liver metastasis from lung cancer:analysis of 24 cases

目的探讨导管介入化疗并栓塞治疗肺癌肝转移的临床效果。方法将肺癌肝转移患者48例随机分为观察组24例和对照组24例。观察组采用超选择插管行化疗药物灌注并超液态碘化油栓塞治疗,对照组仅给予常规的抗肿瘤药物治疗,观察其治疗后白细胞、肝功能、临床症状和生存率的变化情况。结果两组治疗前白细胞降低情况、肝功能、临床症状和肿瘤体积变化比较差异无统计学意义(P>0.05);而治疗后两组比较差异有统计学意义(P<0.01)。生存时间比较,3个月和5个月的病死率两组差异无统计学意义(P>0.05),而7个月和12个月的病死率观察组低于对照组(P<0.01)。结论肝动脉介入化疗并栓塞治疗肺癌肝转移副作用小,临床效果比较满意。

Objective To investigate the clinical effect of catheterization chemotherapy and embolization for liver metastasis from lung cancer. Methods Forty-eight patients with liver metastasis from lung cancer randomly divided into two groups ,the observation group of 24 patients and a control group of 24 patients. The observation group was treated by superselective catheterization and infusion of chemotherapy plus liquid iodized oil embolization. The control group was given conventional anticancer therapy. After treatment white blood cells, liver function, clinical symptoms and survival rate of change were observed. Results Before treatment,the differences in leukopenia, liver function, clinical symptoms and tumor volume between two groups were not statistically significant （ P 〉 0. 05 ）. After treatment, the difference in above indexes between two groups were statistically significant （P 〈 0.01 ）. The survival studies showed that there were no statistically difference in the mortality rate in 3 and 5 month between two groups （P 〉0. 05）, while that in 7 and 12 month in the observation group were lower than the control group （P 〈0. 01）. Further study showed that most of the control group died within 7 months, the mortality rate was 83.3%, while the observation group was only 37.5%, there were statistically significant difference between two groups in both indexes （P 〈0. 01 ）. Conclusion Hepatic arterial infusion chemotherapy and embolization for liver metastases from lung cancer have less side effects, and can obtain a more satisfactory clinical results.