摘要
目的研究探讨COPD患者血清IL-8、CK-MB的含量与动脉血气变化的相互关系。方法 A组(COPD伴有呼衰)62例患者及B组(COPD不伴有呼衰)63例患者,测定其患者治疗前后血清IL-8、CK-MB和PaO2、PaCO2的含量。结果治疗前A组血清IL-8、CK-MB含量明显高于B组(P<0.01),治疗后A组血清IL-8、CK-MB较治疗前明显下降(P<0.01);治疗前A组PaO2明显低于B组,且PaCO2明显高于B组(均P<0.01);治疗后A组PaO2明显高于治疗前,且PaCO2明显低于治疗前(均P<0.01);治疗前后B组及治疗后A、B两组PaO2、PaCO2比较无显著性差异(P>0.05)。结论 COPD患者合并缺缺O2、CO2潴留时,细胞炎性因子可显著升高,可伴心肌损害,心肌收缩力减弱而导致心衰。
Objective To explore the relation between IL-8, CK-MB and arterial blood gas in patients with Chronic obstructive pulmonary disease. Methods 62 cases of Chronic obstructive pulmonary disease with respiratory failure was enrolled into group A and 63 cases of Chronic obstructive pulmonary disease without respiratory failure was enrolled into group B. The concentrations of serum IL-8, CK-MB PaO2 and PaCO2 were measured before and after treatment. Results The concentrations of serum IL-8, CK-MB in group A were significandy higher than those in group B before treatment （ P 〈 0.01 ） ; the concentrations of serum IL-8, CK-MB of the patients significantly decreased in group A after treatment （ P 〈 0. 01 ） ; The PaO2 of patients of group A was significantly lower than that of patients of group B, and the PaCO2 of patients of group A was significantly higher than that of patients of group B before treatment （P 〈 0. 01 ） ; The PaO2 in patients of group A after treatment was significantly higher than that before treatment, and the PaCO2 in patients of group A after treatment obviously lower than that before treatment（P 〈0. O1 ） ; The PaO2 of patients in group B before and after treatment, and the PaCO2 in patients between A and B after treatment were compared without significance differences （P 〉 0. 05 ）. Conclusion Patients of COPD with hypoxia and retention of carbon dioxide can significantly increase cell inflammatory factor, complicated with myocardial injury. In the end, cardiac muscle systole decrease can result in heart failure.
出处
《临床肺科杂志》
2012年第2期216-218,共3页
Journal of Clinical Pulmonary Medicine
