COPD急性加重期血清C反应蛋白与前白蛋白检测的临床意义

Clinical significance of C-reactive protein and prealbumin detection during the acute exacerbation of COPD

目的探讨慢性阻塞性肺疾病(COPD)患者急性加重期C反应蛋白(CRP)和前白蛋白检测的临床意义。方法检测56例COPD急性加重期患者治疗前后血浆CRP和前白蛋白水平,同时选择54例正常健康体检者作为正常对照组,对上述检测结果进行比较和分析。结果 COPD急性加重期CRP水平明显升高,治疗后明显下降,且均大于正常对照组表达水平,组间比较差异有统计学意义(P<0.05);COPD急性加重期前白蛋白水平明显下降,治疗后明显上升,且均小于正常对照组,组间比较差异有统计学意义(P<0.05)。结论 CRP和前白蛋白是反映COPD急性加重期感染和疗效判断的敏感指标。

Objective To discuss the clinical significance of C-reactive protein and prealbumin detection during the acute exacerbation of COPD. Methods The leves of CRP and prealbumin in fifty-six patients at the acute exacerbation of COPD before and after treatment were detected. At the same time, fifty-four normal healthy volunteers were choosed as normal control group, and the results were compared and analyzed between the two groups. Results In acute stage of COPD, the patients plasma CRP level increased distinctly, after given therapies, and the plasma CRP level decreased, with a significant difference between the groups, （ The patients had higher value than controls, P 〈 0. 05 ）In acute stage of COPD, the patients＇plasma prealbumin level decreased distinctly, after given therapies, and the plasma prealbumin level increased, with a significant difference between the groups, （ The patients had lower value than the controls, P 〈 0. 05）. Conclusions Plasma CRP level and prealbumin were sensitive indexes to infection and curative effect judgment.