免疫治疗在初治肺结核中的作用

The effect of immunotherapy on pulmonary tuberculosis under initial treatment

目的探讨免疫治疗在初治肺结核中的作用。方法将2008年1月～2010年12月门诊和住院的初治肺结核随机分成观察组和对照组,观察组在对照组基础上加胸腺肽免疫治疗,检测两组身体质量指数(BMI)、血清白蛋白(ALB)、痰菌变化、胸片(胸部CT)变化。结果观察组的身体质量指数、血清白蛋白、痰菌变化、胸片(胸部CT)变化明显高于对照组,具有显著性差异(P<0.05)。结论初治肺结核的营养不良发生率高、痰菌阳性率高、空洞发生率高,病情较重,应尽可能加用免疫治疗,促进疾病康复,减少后遗症和复发。

Objective To explore the effect of immunotherapy on pulmonary tuberculosis under initial treatment. Methods Patients with outpatient services and in hospital from Jan. 2008 to Dec. 2010 were randomly divided into two groups： control group and treatment group. Patients in the treatment group were treated with thymopeptide immunotherapy in addition to all the treatments used for the control group. The body Mass Index （BMI）, serum albumin （ALB）, change of mycobacterium tuberculosis （MTB） in sputum, and change in chest CT were measured in both groups. Results The BMI, ALB, change of MTB, and change of chest CT of the treatment group were higher than those of the control group, and the differences were significant （P 〈 0. 05 ）. Conclusion Due to high probability of malnutrition, MTB in sputum, and cavity, and the seriousness of the patients＇condition during pulmonary tuberculosis under initial treatment, the patients should be treated with immunotherapy as far as possible in addition in order to other treatments to improve rehabilitation and to reduce sequel and/or recrudescence.