摘要
目的比较研究甘草酸二胺肠溶胶囊对抗结核药物性肝损(ATDH)。方法将80例确诊初发肺结核患者随机分为实验组、对照组和空白组,分别施用甘草酸二胺肠溶胶囊、双环醇片和不用保肝药,观察180天标准抗结核治疗过程中的AT-DH发生情况及检测相关指标。结果实验组ATDH发生率25%,出现ATDH时间为101.20±23.70天;对照组ATDH发生率34.3%,出现ATDH时间为34.42±6.072天;空白组发生率44%,出现ATDH时间50.91±12.03天。实验组ATDH出现时间显著延后(P=0.007)。结论甘草酸二胺肠溶胶囊可延后ATDH的发生时间,降低其严重程度,并缓解抗结核期间炎性过敏反应。
Objective To Compare the preventive effect of glycyrrhizin diamine enteric-coated capsules on ATDH. Methods 80 patients, who were confirmed tuberculosis, were randomly divided into the test group, control group and blank group. Glycyrrhizin diamine enteric-coated capsules, bicyclols and without drugs were respectively applied, the occurrence of ATDH were observed and related indica- tors were detected during 180 days in the standard anti-TB treatment. Results ATDH incidence in the test group was 25%, and it appeared at 101.20 ± 23.70 day;ATDH incidence in the control group was 34. 3% , and it appeared at 34. 42 ±6. 072 day. And the incidence in the blank group was 44% , and it appeared at 50. 91 ± 12. 03 day. The test group was significantly delayed( P = 0. 007 ) , and ALT values were lower( P = 0. 046). Multiple comparisons in eosinophil ratio of the three groups, showed that the test group was significantly lower than the control group and blank group ( P = 0. 024 ). Conclusions Glycyrrhizin diamine enteric-coated capsules may delay the occurrence of ATDH, reduce their severity, and alleviate allergic inflammation in tuberculosis.
出处
《临床肺科杂志》
2012年第2期286-288,共3页
Journal of Clinical Pulmonary Medicine
关键词
抗结核治疗
药物性肝损
预防治疗
anti-tuberculosis therapy
hepatotoxicity
preventive treatment