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阿利吉仑的抗高血压和心、肾、血管保护作用 被引量：4

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摘要 直接肾素抑制剂是一类既能良好降压又具有心血管和肾保护作用的抗高血压药物,其中,当属阿利吉仑研究最多。
作者 张阳阳 王安才
机构地区 皖南医学院弋矶山医院老年医学科
出处 《疑难病杂志》 CAS 2012年第1期73-75,共3页 Chinese Journal of Difficult and Complicated Cases
关键词 阿利吉仑 抗高血压 心血管保护 蛋白尿
分类号 R544.1 [医药卫生—心血管疾病]
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参考文献20

  • 1Schmieder RE,Philipp T,Guerediaga J,et al.Long-term antihypertensive efficacy and safety of the oral direct rennin inhibitor aliskiren:a 12-month randomized,double-blind comparator trial with hydrochlorothiazide[J].Circulation,2009,119(3):417-425.
  • 2Uresin Y,Taylor AA,Kilo C,et al.Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension[J].J Renin Angiotensin Aldosterone Syst,2007,8(4):190-198.
  • 3Dahlof B,Anderson DR,Arora V,et al.Aliskiren,a direct rennin inhibitor,provides antihypertensive efficacy and excellent tolerability independent of age or gender in patients with hypertension[J].J Clin Hypertens,2007,9(Suppl A):A15-20.
  • 4Dparil S,Yarows SA,Patel S,et al.Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension:a randomi-sed,double-blind trial[J].Lancet,2007,370(9583):221-229.
  • 5Black HR,Weinberger MH,Purkayastha D,et al.Comparative efficacy and safety of combination aliskiren/amlodipine and amlodipine monotherapy in African Americans with stage 2 hypertension[J].J Clin Hypertens,2011,13(8):571-581.
  • 6Morgado MP,Rolo SA,Castelo-Branco M.Efficacy of aliskiren/hydrochlorothiazide combination for the treatment of hypertension:a meta-analytical approach[J].Open Cardiovasc Med J,2011,5(1):6-14.
  • 7Jordan J,Engeli S,Boye SW,et al.Direct rennin inhibition with aliskiren in obese patients with arterial hypertension[J].Hypertension,2007,49(5):1047-1055;.
  • 8Pool JL,Schmieder RE,Azizi M,et al.Aliskiren,an orally effective rennin inhibitor,provides antihypertensive efficacy alone and in combination with valsartan[J].Am J Hypertens,2007,20(1):11-20.
  • 9Major TC,Olszewski B,Rosebury W,et al.A nonpeptide,piperdine rennin inhibitor provides renal and cardiac protection in double-teansgenic mice expressing human rennin and angiotensinogen genes[J].Cardiovasc Drugs Ther,2008,10(5):469-478.
  • 10Dong YF,Liu L,Kataoka K,et al.A liskiren prevents cardiovascular complications and pancreatic injury in a mouse model of obesity and type 2 diabetes[J].Diabetologia,2010,53(1):180-191.

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疑难病杂志
2012年 第1期

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