期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

他汀类药物非降脂作用对慢性肾脏病的防治 被引量：3

下载PDF
导出
摘要 他汀类药物是最为经典和有效的降脂药物,此类药物通过竞争性抑制内源性胆固醇合成限速酶羟甲基戊二酰辅酶A（HMG-CoA）还原酶,阻断细胞内甲羟戊酸代谢途径,使细胞内胆固醇合成减少,从而反馈性刺激细胞膜表面（主要为肝细胞）低密度脂蛋白（LDL）受体数量和活性增加,使血清胆固醇清除增加,水平降低。研究证实他汀类药物还具有不依赖于降脂的多效性作用,主要有抗细胞增殖、抗氧化清除自由基、
作者 张立 石生源 赵亮 刘小林
机构地区 解放军防空兵学院门诊部 河南省焦作市武陟县中医院 河南省焦作市武陟县第一人民医院
出处 《检验医学与临床》 CAS 2012年第1期62-64,共3页 Laboratory Medicine and Clinic
关键词 他汀类药物 慢性肾脏病 小GTP蛋白
分类号 R972.6 [医药卫生—药品]
  • 相关文献

参考文献22

  • 1Heusinger RJ, Fischer B, Goppelt SM, et al. Differential effects of simvastatin on mesangial cells[J]. Kidney Int, 2004,66 (1):187-195.
  • 2Bussolati B,Deregibus MC, Fonsato V,et al. Statins pre- vent ox-idized LDL-induced injury of glomerular podo- cytes by activating the phosphatidylinositol 3-kinase/ AKT- signaling pathway[J]. J Am Soc Nephrol,2005,16 (7):1936-1947.
  • 3Kwak B,Mulhaupt F,Myit S,et al. Statins as a newly rec- ognized type of immunomodulator[J]. Nat Med, 2OO0, 6(12):1399-1402.
  • 4Massy ZA, Kim Y, Guljarro C, et al. I.ow-density lipopro rein-induced expression of interleukin-6, a marker of human mesangial cell inflammation: effects of oxidation and modulation by lovastatin[J]. Biochem Biophys Res Com- mun,2000,267 (2) :536-540.
  • 5Vieira JM Jr, Rodrigues LT, Mantovani E, et al. Statin monotherapy attenuates renal injury in a salt sensitive hypertension model of renal dlsease[J]. Nephron Physiol, 2005,101 (4) :p82-p91.
  • 6Buemi M. Senatore M, Corica F, et al. Slatins and progres sire renal diseasee[J]. Mecl Res Rev,2002,22 (1):76 84.
  • 7I.enda DM, kikawada E, Stanley ER, et al. Reduced mac rophage recruitment proliferation and activation in colony stimulating factor-l-deficient mice results in decrease tu- bular apoptosis during renal inflammation[J]. J Immunol, 2003,170 (6) : 3254-3262.
  • 8Massy ZA, Ouijarro C. Statin: effects beyond cholesterol lowerin[J]. Nephro DiM Transplant, 2001,16 ( 9 ) : 1738- 1741.
  • 9Jandeleit DK, Cao Z, Cox AJ, et al. RoLeofhyperlipi- demiainpro 2 gressiverenal diseasefocuson diabeticne phropathy[J]. Kidney Int, 19 9 9,5 6 ( Suppl 71 ) : 31-36.
  • 10Vasantha K, Lixia Z, ttui P, et al. Targeting of rhoA/ ROCK signaling ameliorates progression of diabetic ne phropathy independent of glucose control [J]. Diabetes, 2008,57(3) :714-723.

二级参考文献7

  • 1Evans JL,Goldfine ID,Maddux BA,et al.Oxidative stress and stress-activated signaling pathway:a unifying hypothesis of type 2 diabetes[J].Endoceine Reviews,2002,23(5):599-622.
  • 2Catherwood MA,Powell LA,Anderson P,et al.Glucoseinduced oxidative stress in mesangial cells[J].Kidney Int,2002,61(2):599-608.
  • 3FG Cosio.Effects of high glucose concentrations on human mesangial cell proliferation[J].J Am Soc Nephrol,1995,5(8):1600-1609.
  • 4Danesh FR,Kanwar YS.Modulatory effects of HMG-CoA reductase inhibitors in diabetic microangiopathy[J].FASEB J,2004,18(7):805-815.
  • 5Okada M,Yangida H,Kuwajima H,et al.Antiproliferative effect of fluvastatin and thiazolidinedione in mesangial cells of diabetic rats[J].Pediatr Nephrol,2004,19(1):26-32.
  • 6Usui H,Shikata K,Matsuda M,et al.HMG-CoA reductase in-hibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats[J].Nephrol Dial Transplant 2003,18(2):265-272.
  • 7Chen HC,Tan MS,Guh JY,et al.Native and oxidized LDL enhance superoxide production from diabetic rat glomeruli[J].Kidney Blood Press Res,2000,23(2):133-137.

共引文献6

同被引文献7

引证文献3

二级引证文献7

检验医学与临床
2012年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部