艾普拉唑联合莫沙必利治疗反流性食管炎疗效观察

Efficacy of Ilaprazole combined with mosapride in the treatment of reflux esophagitis

目的观察艾普拉唑联合莫沙必利治疗反流性食管炎的效果。方法 96例临床症状及内镜检查明确诊断为反流性食管炎的患者,随机分为艾普拉唑组49例、奥美拉唑组47例。艾普拉唑组口服艾普拉唑10 mg,2次/d;奥美拉唑组口服奥美拉唑20mg,2次/d;两组同时均加用莫沙必利5 mg,3次/d餐前服,疗程4周。治疗过程中定期观察症状改善情况、检测基础胃酸分泌,疗程结束时内镜复查。结果在缓解症状、降低基础胃酸分泌、改善食管炎症等方面,艾普拉唑组优于奥美拉唑组(P<0.05)。结论艾普拉唑联合莫沙必利治疗反流性食管炎,能有效持续降低胃酸分泌,减少食管酸反流,促进食管黏膜修复,缓解胃食管反流症状。

Objective To investigate the efficacy of Ilaprazole combined with mosapride in treatment of reflux esoph- agitis. Methods 96 cases with reflux esophagitis diagnosed by clinical symptoms and endoscopy were randomly divided into two group. Ilaprazole group （49 cases） were treated with Ilaprazole l0 rag, two times a day; Omeprazole group （47cases） were treated with omeprazole 20 mg two times a day; all patients also were treated with mosapride 5 mg, three times a day before meal service. Total courses were four weeks. The improvement of clinical symptoms in the course of treatment, the basic gastric acid secretion and endoscopy reexamining were detected at the end of treatment. Results Better results were found in Ilaprazole group compared with the Omeprazole group in alleviating clinical symptoms, re- ducing the basis of gastric acid secretion and improving esophageal inflammation. Conclusion Ilaprazole combined with mosapride can reduce the secretion of gastric acid standing and effectively, reduce esophageal acid reflux, promote e- sophageal mucosa repair and relieve clinical symptoms of gastroesophageal reflux.