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Smac/DIABLO与消化系统肿瘤关系的研究进展

Relationship between Smac/DIABLO and digestive system tumors
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摘要 Smac/DIABLO(the second mitochondrial activator of caspase/direct IAP binding protein with low pI)是一种新发现的线粒体蛋白,在细胞发生凋亡时,与细胞色素c一起被线粒体释放到胞质中,与IAPs结合,解除IAPs对caspase的抑制,从而诱导细胞凋亡。Smac这种促凋亡作用对消化系统肿瘤的发生、发展以及肿瘤的治疗具有重要意义。 Smac/DIABLO （the second mitochondrial activator of caspase/direct IAP binding protein with low pI） is a new found mitochondrial protein that is released to the cytosol with eytochrome e when a cell is triggered to undergo pro- grammed cell death. It promotes apoptosis through its ability to adhere to lAPs, inhibiting their easpase-binding activity.
作者 李淑芹 关景明
机构地区 哈尔滨医科大学附属第二医院消化科
出处 《胃肠病学和肝病学杂志》 CAS 2011年第12期1157-1159,共3页 Chinese Journal of Gastroenterology and Hepatology
关键词 SMAC 细胞凋亡 消化系统肿瘤 Smac Apoptosis Digestive system tumors
分类号 R735 [医药卫生—肿瘤]
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胃肠病学和肝病学杂志
2011年 第12期

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