锌对钛种植体骨融合的影响

Effect of zinc on titanium implant bone fusion

背景：前期的研究结果表明,补锌能够提高种植体的骨愈合率以及固位强度。目的：观察锌对种植体骨界面组织形态的影响。方法：纳入成年雄性家兔40只,双侧胫骨近心端各置入1枚钛种植体,建立钛种植体动物模型,分为补锌组和对照组。补锌组动物肌注10g/L硫酸锌,4mg/kg,1次/d;对照组给予同剂量生理盐水。分别于术后1,2,4,8,12周处死动物,利用显微镜及扫描电镜观察种植体-骨界面组织形态。结果与结论：补锌能够在钛种植体置入后1~4周内加速种植体-骨界面的新骨形成,促进种植体骨愈合。提示种植体置入后适量地补锌能够促进新骨形成,提高骨愈合的速度和质量。

BACKGROUND： Previous research has testified that zinc can improve the healing rate and enhance the fixation strength of implants. OBJECTIVE： To observe the effect of zinc on the morphology of implant-bone interface. METHODS： Forty adult male rabbits were involved and divided into zinc supplement group and control group. The titanium implants were implanted into bilateral tibias at the proximal end to establish animal models of titanium implants. Zinc sulfate of 10 g/L was administered intramuscularly to the animals in the zinc supplement group at the dose of 4 mg/kg once per day, and those in the control group were treated with saline at the same dose. The animals were killed at 1, 2, 4, 8 and 12 weeks after treatment. Stereomicroscope and scanning electron microscopy were used to observe the morphology of the implant-bone interface. RESULTS AND CONCLUSION： Zinc supplement could accelerate the new bone formation on the implant-bone interface at 1-4 weeks after treatment to facilitate the fusion between the implant and bone. It is indicated that amount of zinc supplement can promote the new bone formation and enhance the speed and quality of bone healing.