壳聚糖在肿瘤放射治疗中的作用及应用

Application and role of chitosan in tumor radiotherapy

背景:通过增敏剂来提高放射治疗效果是目前肿瘤放疗领域的研究热点之一。壳聚糖具有良好的生物相容性和生物降解性也可作为一种多功能的放疗增敏剂,运用于放射治疗的协同治疗。目的:对近年国内外关于壳聚糖在肿瘤放疗中的研究现状、应用原则以及发展趋势进行综述。方法:计算机检索中国期刊全文数据库(CNKI)、维普中文科技期刊数据库(VIP)、万方数据库(IPSEN)、中国生物医学文献据库(CBM)、Elsevier数据库和Pubmed数据库,收集到1995/2008发表有关壳聚糖生物作用研究的中英文文献194篇阅读标题和摘要进行初筛,共保留其中的48篇归纳总结,从壳聚糖的自身抗肿瘤效应、对放射治疗的增敏作用以及对正组织保护作用三方面分析,以进行壳聚糖对放疗增敏性的研究总结。结果与结论:从壳聚糖抗肿瘤效应、对放射治疗的增敏作用以及对正常组织保护作用的实验中,证实了壳聚糖可作为一种功能的放疗增敏剂。

BACKGROUND： Currently, the improvement in the effect of radiation therapy by sensitizer is one of the hotspot in tumor radiotherapy field. Chitosan has a good biocompatibility and biodegradability, and can be used as a kind of multi-functional sensitizer to apply in radiotherapy for synergy therapy. OBJECTIVE： To summarize the research status, application principle and development of chitosan applied in tumor radiotherapy at home and abroad recently. METHODS： A computer-based online search of literatures related to biological effect of chitosan published between 1995 and 2009 in CNKI database, VIP database, Wanfang database, China Biology Medicine disc, Elsevier database and PubMed database was performed. Totally 194 articles in Chinese and in English were collected. 48 of them were chosen to summarize according to inclusion criteria. The anti-tumor effect, radiation sensitizing effect and protective effect on the normal tissues of chitosan were analyzed to summarize its radiosensitivity. RESULTS AND CONCLUSION： Chitosan has been proved to be a kind of multi-functional sensitizer for radiotherapy by the experiments of the anti-tumor effect, radiation sensitizing effect and protective effect on the normal tissues of chitosan.