丝素蛋白的生物相容性及临床应用

Biocompatibility and clinical application of silk fibroin

背景:皮肤损伤后的修复和重建都是棘手的问题,以皮肤细胞本身作为皮肤替代物修复缺损,以达到恢复组织器官的形态和功能,成为一种理想的途径,也是临床上难以解决的问题目的:文章综述了丝素蛋白的生物相容性及应用的研究进展,寻找最佳人工皮肤以应用临床。方法:应用计算机检索CNKI和PubMed数据库中1992-02/2011-03关于丝素蛋白生物相容性,在组织工程皮肤、生物材料领域应用的文章,在标题和摘要中以"丝素蛋白;生物相容性;组织工程;生物材料;应用"或"Silk fibroin;Biocompatibility;Tissue Engineering;Biological materials;Application"为检索词进行检索。选择文章内容与丝素蛋白的生物相容性及应用相关,同一领域文献则选择近期发表或发表在权威杂志文章。初检得到215篇文献,根据纳入标准选择22篇文章进行综述。结果与结论:对丝胶蛋白特性及研究应用的了解,有利于皮肤损伤后的修复和重建,以皮肤细胞本身作为皮肤替代物修复缺损,以达到恢复组织器官的形态和功能,有良好的机械性能和理化性质及有良好的生物相容性,对表皮细胞生长具有一定的促进作用。但将其应用于临床治疗方面仍需要很长的时间,尚有一些问题需要进一步研究、解决。

BACKGROUND：Repair and reconstruction after skin injury are difficult.It is an ideal approach to repair defects using skin cells to restore tissue and organ appearance and function.However,this problem remains resolving in clinic.OBJECTIVE：To summarize biocompatibility and application advances in silk fibroin to search the optimal artificial skin.METHODS：A computer-based online search of CNKI and PubMed database was performed for articles related to biocompatibility of silk fibroin and its application in tissue engineered skin and biomaterials,with keywords ＂silk fibroin;biocompatibility;tissue engineering;biological materials;application＂ in Chinese and English.Articles published recently in authoritative journals regarding biocompatibility and application of silk fibroin were selected.215 articles were collected and 22 were included.RESULTS AND CONCLUSION：Understanding of properties and application of silk fibroin can benefit repair and reconstruction after skin injury.Repairing defects using skin cells to restore tissue and organ appearance and function exhibits mechanical performance and physiochemical properties,as well as biocompatibility.Moreover,it can promote epidermic cell growth.However,some issues need to resolve for clinical treatment.