糖尿病大鼠股骨头血管内皮功能障碍的变化

Variations of vascular endothelial dysfunction of the femoral head in diabetic rats

背景:糖尿病骨病的并发症起病复杂,骨组织血管内皮病变可能是造成的一个重要原因。目的:探讨糖尿病对大鼠股骨头内皮功能障碍的影响。方法:将60只大鼠随机等分为对照组和糖尿病组,糖尿病组大鼠腹腔注射链脲佐菌素建立糖尿病模型。结果与结论:造模15周时,与对照组相比,糖尿病组大鼠股骨头出现骨质疏松显微结构改变,血清一氧化氮水平明显降低,血浆内皮素1水平明显升高,糖尿病组股骨头凝血因子Ⅷ表达明显减少(P<0.01),提示糖尿病前期就出现内皮功能障碍。微血管增生,糖尿病诱发内皮功能障碍及相互作用与大鼠股骨头功能减退有关。

BACKGROUND： Onset reason of the complications of diabetic osteopathia is complicated. Endothelial lesions of blood vessel in bone tissue may play an important role in onset reason. OBJECTIVE： To investigate the effects of diabetes on endothelial dysfunction of the femoral head in the rats. METHODS： Totally 60 rats were randomly divided into diabetic group and control group. Diabetic model was constructed by intraperitoneal injection of streptozotocin in the diabetic group. RESULTS AND CONCLUSION： Compared with the control group at 15 weeks after modeling, microstructure of the femoral head in the rats was changed, serum levels of nitric oxide level was significantly decreased, plasma endothelin 1 was significantly increased and expression of blood coagulation factorⅧ was significantly decreased in the diabetic group （P 0.01）. It is indicated that the endothelial dysfunction occurs in the prediabetes. Endothelial dysfunction is induced by micrangium accrementition and diabetes, which are related with the hypofunction of the femoral head in the rats.