成人社区获得性肺炎患者血浆可溶性p-选择素与C反应蛋白、血小板间关系的临床分析

Clinical analysis of relationship of plasma soluble P-selectin concentration with C-reactive protein and platelet in adult community-acquired pneumonia

目的探讨成人社区获得性肺炎（CAP）患者血浆可溶性P-选择素（sPs）浓度的演变趋势，结合炎症指标C反应蛋白（CRP）、血小板（PLT）的变化，了解sPs的临床作用。方法将CAP患者分为2组：A组为36例CAP并发继发性血小板增多症（ST）患者，B组为36例无ST的CAP患者，分别检测观察对象5次的sPs浓度、CRP、PLT的数值，即入院0h、24h、48h、72h和痊愈出院时；对照组为180名健康成人，分别检测sPs浓度、CRP和PLT。结果A组sPs、CRP、PLT均较B组高（P〈0．01），三项指标间有正相关关系，sPs与CRP相关性最好（r=0．749，P〈0．01）。结论结合CRP、PLT等炎症指标，连续检测CAP患者sPs浓度对CAP病情的判断、治疗和预后可能有一定的临床价值。

Objective To understand the soluble P-selectin clinical effects, and analyse the evolution tendency of the plasma soluble P-selectin （sPs） concentration of adult community-acquired pneumonia （CAP） patients. The inflammatory biomarkers changes of C-reactive protein （CRP） and platelet （PLT） were analysed at the same time. Methods The patients were divided into two groups： group A：CAP with secondary thrombocytosis （ST） （ n =36）;group B：CAP simply （ n =36）. The sPs concentration,the CRP and the PLT were detected when the patients were admitted, and 24 h,48 h,72 h later, and the patients recovered to discharge. In control group （ n =180）, the sPs concentration, the CRP and the PLT were detected once. Results The PLT,sPs and CRP of the patients in group A were higher than those in group B （P 〈 0.01）. There were positive correlation in the three indexes, the best correlation was between sPs and CRP （r = 0. 749, P 〈 0.01 ）. Conclusions Combined with the inflammation biomarkers including CRP and PLT,continuous detecting the concentration of sPs may have some useful clinical value in the judgement,treatment and prognosis of the CAP patients.