新疆地区活体肾移植178例随访

Clinical effects of living donor kidney transplantation in 178 cases from Xinjiang area

背景:新疆的特殊之处在于是国内少数民族与汉族混杂聚集地,新疆地区目前尚无少数民族与汉族间活体肾移植有种族差异的明确报道。目的:比较新疆地区少数民族与汉族间活体肾移植的种族差异。方法:回顾性分析新疆地区1999/2010行活体肾移植受者的临床资料,并对移植前、后一般临床资料,以及移植后少数民族与汉族间移植肾存活率进行比较分析,将可能影响移植肾存活率的各种因素进行单因素分析。结果与结论:纳入随访资料完善者178例,其中少数民族131例,汉族47例。汉族组受者的移植肾存活率较少数民族组患者稍高,但差异无显著性意义。对可能影响长期移植肾生存的因素进行Cox单因素分析,显示急性排斥反应对移植肾生存有明显影响。提示新疆地区不同民族间接受同种民族活体肾移植的短中期移植肾存活率差异无显著性意义,急性排斥反应为影响移植肾存活的重要因素。

BACKGROUND： Xinjiang is a rare region where populations of minority and Han nationalities live together. There have been no confirmative reports describing race difference in living donor kidney transplantation between population of minority nationality and population of Han nationality. OBJECTIVE： To summarize and analyze Xinjiang living kidney transplantation and clinical experience to provide clinical guidance. METHODS： A retrospective analysis of clinical data of living kidney transplantation recipients who underwent kidney transplantation between 1999 and 2010 in Xinjiang. Preoperative general condition and postoperative complications of the living kidney recipients, and graft survival rate after transplantation in population of minority nationality versus population of Han nationality were analyzed. One-way analysis of variance was performed to analyze various factors that may influence graft survival rate. RESULTS AND CONCLUSION： A total of 178 patients provided complete follow up data, including 131 patients of minority nationality and 47 patients of Han nationality. The graft survival rate was slightly higher, but not significantly, in the recipients of Han nationality than in those of minority nationality. Cox analysis of factors that may influence survival rate of grafts showed that acute rejection greatly influences graft survivals. These findings suggest that the short- and medium-term graft survival rate is similar between populations of different nationalities in Xinjiang who receive living kidney transplantation and acute rejection is the important factor that influences graft survival rate.