摘要
目的:探讨黄芩苷片对脑梗死患者的临床疗效及其治疗机制。方法:51例急性脑梗死患者被随机分为两组:常规治疗组(28例)和干预组(给予黄芩苷片治疗,23例),并随访1月。其间,收集入院后24小时、120小时血液样本用于炎症因子和氧化应激水平的检测。实验末期评估患者治疗前后临床疗效。结果:经过1月的治疗,两组患者的总有效率分别为78.57%,86.96%(p>0.05)。但是干预组的神经功能、认知障碍和日常生活能力的恢复明显优于常规治疗组(p<0.01);同时120小时血清中炎症因子(TNF-α)和氧化应激的水平也显著降低(p<0.05)。结论:黄芩苷可以用于脑梗死患者的临床治疗,其临床获益可能与抗炎抗氧化作用有关。
Objective:To observe the clinical effects of baicalin in treating patients with cerebral infarction.Methods:Fifty-one patients with acute cerebral infarction were randomly divided into two groups: conventional therapy group(n=28) and intervention group(n=23).After admission,24h and 120h blood were collected for detection of inflammatory factors and oxidative stress.The treatment lasted one month and clinical efficacy was assessed at the end of the experiment.Results:The efficacy of conventional therapy group and intervention group was 78.57% and 86.96% respectively,(p0.05).However the recovery of neurological,cognitive function and activity of daily living in intervention group was much better compared to the conventional therapy group(p0.01).At the same time,120h serum inflammatory factors(TNF-α) and oxidative stress levels were also significantly lower(p0.05) in intervention group.Conclusions: Baicalin might be applied to cerebral infarction patients,whose clinical effects may be related to the properties of anti-inflammation and antioxidant.
出处
《川北医学院学报》
CAS
2011年第6期536-539,共4页
Journal of North Sichuan Medical College
关键词
脑梗死
黄芩苷
炎症
氧化应激
Cerebral infarction
Baicalin
Inflammation
Oxidative stress