黄芩苷片对脑梗死患者的临床疗效观察及机制探讨

An Investigation of the Efficacy and Mechanism of Baicalin on Cerebral Infarction Patients

目的:探讨黄芩苷片对脑梗死患者的临床疗效及其治疗机制。方法:51例急性脑梗死患者被随机分为两组:常规治疗组(28例)和干预组(给予黄芩苷片治疗,23例),并随访1月。其间,收集入院后24小时、120小时血液样本用于炎症因子和氧化应激水平的检测。实验末期评估患者治疗前后临床疗效。结果:经过1月的治疗,两组患者的总有效率分别为78.57%,86.96%(p>0.05)。但是干预组的神经功能、认知障碍和日常生活能力的恢复明显优于常规治疗组(p<0.01);同时120小时血清中炎症因子(TNF-α)和氧化应激的水平也显著降低(p<0.05)。结论:黄芩苷可以用于脑梗死患者的临床治疗,其临床获益可能与抗炎抗氧化作用有关。

Objective：To observe the clinical effects of baicalin in treating patients with cerebral infarction.Methods：Fifty-one patients with acute cerebral infarction were randomly divided into two groups： conventional therapy group（n=28） and intervention group（n=23）.After admission,24h and 120h blood were collected for detection of inflammatory factors and oxidative stress.The treatment lasted one month and clinical efficacy was assessed at the end of the experiment.Results：The efficacy of conventional therapy group and intervention group was 78.57% and 86.96% respectively,（p0.05）.However the recovery of neurological,cognitive function and activity of daily living in intervention group was much better compared to the conventional therapy group（p0.01）.At the same time,120h serum inflammatory factors（TNF-α） and oxidative stress levels were also significantly lower（p0.05） in intervention group.Conclusions： Baicalin might be applied to cerebral infarction patients,whose clinical effects may be related to the properties of anti-inflammation and antioxidant.