干细胞移植治疗糖尿病

Stem cells transplantation for treatment of diabetes mellitus

背景:干细胞移植可以从细胞和基因水平治疗糖尿病,从而达到临床治愈。目的:综述近年来国内外干细胞移植治疗糖尿病的相关研究进展。方法:应用计算机检索2000-01/2010-06PubMed数据库、中国期刊全文数据库相关文章,检索词为"stemcells,diabetesmellitus,transplantation,insulin-secretingcell,treatment;干细胞,糖尿病,移植,胰岛素分泌细胞,治疗",共纳入27篇文章进行综述。结果与结论:糖尿病是一组由于胰岛素绝对或相对不足所引起的以慢性高血糖为特征的代谢性疾病,目前尚无根治的方法。干细胞具有极强的自我更新和多向分化潜能,可诱导分化为胰岛素分泌细胞,在体内和体外发挥调节血糖的作用,成为胰岛β细胞替代物的新资源。目前干细胞移植治疗糖尿病已在动物实验和小规模临床研究中取得了一定成果。

BACKGROUND：Stem cells transplantation can treat diabetes mellitus on cell and gene levels to achieve clinical cure.OBJECTIVE：To review the research progress addressing stem cells transplantation for diabetes mellitus.METHODS：A computer based search was conducted in PubMed database and Chinese Journal Full-text database for relevant articles published from January 2000 to June 2010,with keywords of ＂stem cells,diabetes mellitus,transplantation,insulin-secreting cell,treatment＂ in English and Chinese,respectively.A total of 27 articles were reviewed.RESULTS AND CONCLUSION：Diabetes mellitus is a group of metabolic disease characterized by chronic high blood sugar,which is caused by absolute or relative deficiency of insulin.Currently there is no treatment to cure it.Stem cells have a strong self-renewal and differentiation potential,which can be induced to differentiate into insulin-secreting cells to regulate blood sugar in vivo and in vitro,and they become the new resource of a substitute of islet β cells.At present,stem cells transplantation on treatment of diabetes mellitus has made some progress in animal experiments and small-scale clinical studies.