usp22和ki67在大肠癌组织中的表达及其临床意义

Expression and Clinical Significance of usp22 and ki67 in Colorectal Carcinoma

目的检测usp22和ki67在大肠癌组织中的表达,探讨其与大肠癌发展的关系以及两者的相关性。方法采用免疫组织化学法检测usp22和ki67在大肠癌和正常肠组织中的表达。结果在大肠癌中,usp22的阳性表达率以及染色强度均随组织分化程度的降低而呈现出上升趋势(P<0.05)。ki67的阳性表达率随分化程度的降低而呈现出上升趋势(P<0.05)。usp22与ki67的表达呈现正相关性。结论在大肠癌组织中usp22的高表达与ki67的表达升高显示二者存在正相关,对大肠癌的发生发展起一定促进作用。

Objective To investigate the expression of usp22 and ki67 in colorectal carcinoma and to study their correlation with tumorigenesis and progression of colorectal carcinoma. Methods The expression of usp22 and ki67 in specimens was detected by immunohistochemistry. The correlation between expression of usp22 and ki67,and the relationship of their expressions with clinicopathological factors was statistically analyzed. Results The expression of usp22 and ki67 was upregulated with decrease of differentiation lev- el in eolorectal carcinoma（P0.05）. In coloreetal carcinoma,the expression level of usp22 was positively correlated with that of ki67 （r = 0. 4066,P0.05）. Conclusion In colorectal carcinoma, both usp22 and ki67 was upregulated,meanwhile they are positive correlated. These findings suggest that usp22 and ki67 may play important roles in the tumorigenesis and progression of carcinoma.