三维适形放疗联合小剂量顺铂治疗老年非小细胞肺癌的疗效观察

Three Dimensional-conformal Radiotherapy Combined with Low-dose Cisplatin in Treatment of Elderly Non-small Cell Lung Cancer

目的观察三维适形放疗联合小剂量顺铂治疗老年非小细胞肺癌(NSCLC)的疗效和不良反应。方法回顾性分析36例年龄≥75岁的老年非小细胞肺癌患者在接受三维适形放疗50～60 Gy,同步静脉应用顺铂40 mg,1次/周至放疗结束,放化疗结束两周后的疗效及不良反应。结果 36例患者中完全缓解(CR)7例,部分缓解(PR)19例,稳定(SD)6例,进展(PD)4例,总有效率(CR+PR)为72.2%,临床获益率(CR+PR+SD)为88.9%。放射性食管炎、轻度胃肠道反应和Ⅰ～Ⅱ度骨髓抑制是主要的不良反应。结论三维适形放疗联合小剂量顺铂治疗年龄≥75岁的老年非小细胞肺癌疗效较好,不良反应轻,耐受性好,值得临床广泛应用。

Objective To investigate the effect and toxicity of treatment with three dimensional-conformal radiotherapy and low dose Cisplatin on the elderly patients with non-small cell lung cancer （NSCLC）. Methods To retrospectively analyze the effect and toxicity of 36 elderly NSCLC patients with aging greater or equal to 75 ,all the patients were given 3DCRT with 50-60 Gy and paclitaxe Cisplatin chemotherapy. Results CR was achieved in 7 cases,PR in 19 cases,SD in 6 eases,PD in 4 cases,the overall response rate （CR＋ PR） was 72.2% and the clinical benefit rate （CR＋ PR＋ SD） was 88.90/oo. The important adverse effects were radiation esophagitis,gastrointestinal toxicity and bonemarrow suppression. Conclusion Three dimensional-conformal radiotherapy combined with low-dose cisplatin for elderly patients with non smalI cell lung cancer was safe and effective,the toxicity was tolerable.