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PTEN:白血病防治新靶点 被引量：1

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摘要 0引言与张力蛋白同源的10号染色体缺失的磷酸酶基因（phosphatase and tensin hemology deleted on chromosome ten gene,PTEN）是1997年发现的编码具有脂质磷酸酶和蛋白磷酸酶活性的抑癌基因,具有双重肿瘤抑制功能。
作者 成志勇 潘崚 郭宗伟 任建伟
机构地区 保定市第一医院血液内科 四川大学华西医院血液内科 高阳县医院内科
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2012年第1期105-109,共5页 Cancer Research on Prevention and Treatment
基金 保定市科技攻关计划基金资助项目(11ZF003)
关键词 PTEN 白血病 信号传导 PI3K/AKT
分类号 R733 [医药卫生—肿瘤]
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参考文献37

  • 1Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer[J].Science,1997,275(5308):1943-1947.
  • 2Steck PA, Pershouse MA,Jasser SA, et al. Identification of a candidate tumor suppressor gene, MMC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers[J]. Nat Genet, 1997,15(4) :356-362.
  • 3成志勇,郭晓玲,李世辉,王素云,杨晓阳,薛芳,温树鹏,潘崚.PTEN-FAK信号传导通路在白血病细胞迁移、侵袭中的作用[J].中华血液学杂志,2009,30(2):115-120. 被引量：29
  • 4成志勇,万建设,王亚丽,梁丽青,梁文同,穆敬,芦希,潘崚.PTEN基因对慢性粒细胞白血病Survivin、Xiap、Smac调控的研究[J].中华医学杂志,2011,91(40):2868-2872. 被引量：13
  • 5Stambotic V,Tsao MS, Macpherson D, et al. High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten +/-mice[J].Cancer Res, 2000,60 (13) : 3605- 3611.
  • 6Jiang BH,Liu LZ. PI3K/PTEN signaling in tumorigenesis and angiogenesis [ J ]. Biochim Biophys Acta, 2008, 1784 ( 1 ): 150-158.
  • 7Furukawa K,Kumon Y,Harada H,et al. PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules[J]. Int J Oncol,2006,29(1): 73-81.
  • 8Chung JH, Eng C. Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis[J]. Cancer Res, 2005,65 (18) :8096-8100.
  • 9Blanco-Aparicio C, Pequefio B, Moneo V, et al. Inhibition of pbospbatidylinositol-3-kinase synergizes with gemeitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria [J]. Antieancer Drugs, 2005, 16 ( 9 ) : 977-987.
  • 10Weng LP, Brown JL, Eng C, et al. PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Aktdependent and independent pathways[J]. Hum Mol Genet, 2001,10(3) : 237-242.

二级参考文献35

  • 1Ye-JiangZhou,Yu-XiaXiong,Xiao-TingWu,DeShi,WeiFan,TongZhou,Yue-ChunLi,XiongHuang.Inactivation of PTEN is associated with increased angiogenesis and VEGF overexpression in gastric cancer[J].World Journal of Gastroenterology,2004,10(21):3225-3229. 被引量：31
  • 2成志勇,潘崚,牛志云,梁文同,贾志强,颜晓燕,姚丽,杨敬慈.PTEN基因转染对白血病细胞VEGF调控作用的影响[J].肿瘤,2010,30(10):815-821. 被引量：17
  • 3Myers MP, Stolarov JP, Eng C,et al. PTEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci U S A, 1997,94:9052-9057.
  • 4Tamura M, Gu J, Matsumoto K, et al. Inhibition of cell migration, spreading,and local adhesions by tumor suppressor PTEN. Science, 1998, 280:1614-1617.
  • 5Dahia PL, Aguiar RC, Alberta J,et al. PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies. Hum Mol Genet, 1999, 8 : 185-193.
  • 6Yilmaz OH, Valdez R, Theisen BK, et al. Pten dependence distinguishes haematopoietic stem cells from leukemia-initiating cells. Nature, 2006, 441:475-482.
  • 7Yang J, Liu J, Zheng J,et al. A reappraisal by quantitative flow cytometry analysis of PTEN expression in acute leukemia. Leukemia, 2007, 21:2072-2074.
  • 8Cheong JW, Eom JI, Maeng HY, et al. Phosphatase and tensin homologue phosphorylation in the C-terminal regulatory domain is frequently observed in acute myeloid leukaemia and associated with poor clinical outcome. Br J Haernatol,2003,122:454-456.
  • 9Roman-Gomez J, Jimenez-Velasco A, Castillejo JA, et al. Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia. Blood, 2004, 1048 : 2492-2498.
  • 10Xn Q,Simpson SE,Scialla TJ,et at. Survival of acute myeloid leukemia cells requires PI3 kinase activation. Blood, 2003, 102 : 972-980.

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肿瘤防治研究
2012年 第1期

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