10例睡眠性头痛临床分析

Hypnic headache: ten new cases report

目的分析睡眠性头痛的临床特点,提高对睡眠性头痛的认识和改善治疗效果。方法分析2006年7月至2010年10月诊治的10例睡眠性头痛的临床表现及治疗结果,并结合文献进行总结。结果10例病例中男4例,女6例,发病年龄从24至61岁,全部病例中6例使用了碳酸锂口服治疗,5例头痛发作完全停止,1例无效而改用氟桂利嗪口服治疗,发作停止;3例则使用了洛美利嗪治疗,头痛发作停止;2例(包括上述提到的1例)使用氟桂利嗪治疗发作停止。结论应提高对睡眠性头痛的认识,首选碳酸锂治疗,如果碳酸锂无效或因药物副作用或其它原因不能使用碳酸锂,则可使用洛美利嗪或氟桂利嗪亦有效。

Objective To clinically analyze the feature of hypnic headache in order to improve our cognition toward it. Methods Ten patients, 4 men, 6 women, from 30 to 61 years old, were prospectively analyzed over the past more than 4 years in our hospitals. Results Their ages of onset were from 24 to 61 years old （mean 36.7± 11.03）. Six of the 10 cases were treated with lithium carbonate, out of whom 5 got all complete response. One stopped taking lithium carbonate because of no response. She was treated with flunarizine and complete response was gained. Three of the 10 cases were treated with lomerizine and two （including one case mentioned above） of the 10 cases were treated with flunarizine all complete response. Conclusions Hypnie headache is a rare benign disorder which needs our improved understanding. The patient who is diagnosed with hypnic headache should firstly receive lithium carbonate, or other drugs, flunarizine, lomerizin, is used if she/he can not get relief and （or） tolerate the adverse effects.