8q24 rs13281615单核苷酸多态性与乳腺癌发病风险的Meta分析

Association between a single nucleotide polymorphism in 8q24 rs13281615 and breast cancer risk:a Meta-analysis

目的:探讨8q24 rs13281615单核苷酸多态性(singl enucleotide polymorphism,SNP)与乳腺癌发病风险的关系。方法:检索PubMed、Medline、Embase、中国知网(China National Knowledge Infrastructure,CNKI)和万方数字化期刊等中英文数据库。以乳腺癌病例组和对照组人群基因型分布计算粗比值比(oddsratios,OR)和95%可信区间(95% confidence interval,CI),采用RevMan 5.1软件进行Meta分析和文献偏倚的评估。结果:共纳入7篇研究文献,累积病例22128例,累积对照29276例。采用随机效应模型,与野生纯合子(AA)相比,携带杂合子(AG)和突变纯合子(GG)的妇女发生乳腺癌的合并风险上升(OR=1.14,95%CI:1.04～1.25),尤其是欧洲妇女乳腺癌的发病风险增加(OR=1.14,95%CI:1.02～1.28)。结论:8q24 rs13281615的G等位基因型可能会增加乳腺癌的发病风险。

Objective： To investigate the association between the single nucleotide polymorphism （SNP） in 8q24 rsl3281615 and breast cancer risk. Methods： The studies were identified by searching Chinese and English databases including PubMed, Medline, Embase, China National Knowledge Infrastructure （CNKI） and WanFang Data. The crude odds ratio （OR） and 95% confidence interval （CI） were calculated by the distribution of genotypes in the patients with breast cancer and the controls. The Meta analysis was conducted and the bias in studies was evaluated by RevMan 5.1 software. Results： A total of 7 case- control studies were eligible for this study, including 22 128 cumulative cases of breast cancer and 29 276 controls. The combined risk was higher in the carriers with heterozygous （AG） and homozygous （GG） genotypes than that in the carriers with wild genotype （AA） （OR=1.14, 95% CI： 1.04-1.25） by using random effects model. This effect was especially significant in European women （OR=1.14, 95% CI： 1.02-1.28）. Conclusion： The G allele of 8q24 rs13281615 may increase the risk of breast cancer.