B细胞特异性莫洛尼鼠白血病病毒插入位点-1在胃癌组织中的表达及其临床意义

B-cell-specific Moloney murine leukemia virus integration site-1 expression in gastric carcinoma and its clinical significance

目的:探讨B细胞特异性莫洛尼鼠白血病病毒插入位点-1(B-cell-specific Moloney murine leukemia virus integration site-1,Bmi-1)蛋白在胃癌组织中的表达及其临床意义。方法:应用免疫组织化学法检测正常胃黏膜、慢性非萎缩性胃炎、慢性萎缩性胃炎、异型增生及胃癌组织中Bmi-1、c-myc和Zeste基因增强子同源物2(enhancer of Zeste homolog 2,EZH2)蛋白的表达。结果:Bmi-1蛋白在正常胃黏膜、慢性非萎缩性胃炎、慢性萎缩性胃炎、异型增生和胃癌组织中的阳性表达率分别为5.0%、16.7%、30.7%、58.1%和78.0%,各组间差异有统计学意义(P<0.05)。胃癌组织中Bmi-1高表达率为45.0%,其表达水平与肿瘤大小、分化程度、浸润深度、淋巴结转移和TNM分期有关(P<0.05)。胃癌组织中Bmi-1的表达与c-myc、EZH2表达之间呈正相关(rs=0.567,P<0.001;rs=0.582,P<0.001)。结论:Bmi-1在胃癌组织中表达上调,其高表达与胃癌的分化程度、浸润深度和淋巴结转移有关。

Objective： To investigate the expression of B-cell-specific Moloney murine leukemia virus integration site-1 （Bmi-1） in gastric carcinoma and its clinical significance. Methods： The expressions of Bmi-1, c-myc, and enhancer of Zeste homolog 2 （EZH2） in normal gastric mucosa, chronic non-atrophic gastritis, chronic atrophic gastritis, dysplasia and gastric adenocarcinoma tissues were detected by immunohistochemistry. Results： The positive expression rates of Bmi-1 in normal gastric mucosa, chronic non-atrophic gastritis, chronic atrophic gastritis, dysplasia and gastric carcinoma tissues were 5.0%, 16.7%, 30.7%, 58.1% and 78.0%, respectively. There was a significant difference in positive expression rate of Bmi-1 among different gastric tissues （P〈O.05）. The high expression rate of Bmi-1 （45.0%） in gastric adenocarcinoma tissues was associated with tumor size, differentiation, invasion depth, lymph node metastasis and TNM stage （P〈0.05）. The Bmi-1 expression was positively correlated with the expressions of c-myc （rs = 0.567, P〈0.001） and EZH2 （rs = 0.582, P〈0.001）. Conclusion： The expression level of Bmi-1 is up-regulated in gastric carcinoma, and which is related with differentiation, invasion depth and lymph node metastasis.