化疗期间肠外营养对中晚期胃癌患者免疫功能的影响

Effects of Parenteral Nutrition During Chemotherapy on the Immune Functions of Advanced Gastric Cancer Patients

目的:观察化疗期间肠外营养对中晚期胃癌患者免疫功能的影响。方法:收集江苏省如皋市人民医院自2008年3月至2010年9月间收治的63例接受化疗的中晚期胃癌患者,随机分为观察组(化疗同时给予肠外营养)36例和对照组(化疗期间未给予肠外营养)27例。观察两组患者化疗疗效、平均化疗周期、无进展生存期,检测化疗前后两组患者营养状况和淋巴细胞亚群情况。结果:两组患者近期疗效无显著性差异;观察组平均化疗周期和无进展生存期显著优于对照组;化疗后观察组患者营养状况显著优于对照组;淋巴细胞亚群检测显示观察组患者免疫功能得到改善,显著优于对照组。结论:对中晚期胃癌患者化疗期间给予适当的肠外营养可改善患者的营养状态和免疫功能,患者易于耐受化疗,可取得更好的疗效。

Objective： To observe the effects of parenteral nutrition during chemotherapy on the immune function of advanced gastric cancer patients. Methods： Sixty-three advanced gastric carcinoma patients were admitted to People＇s Hospital of Rugao City between March 2008 and September 2010. Thirty-six patients in the observation group received parenteral nutrition during chemotherapy, whereas 27 patients in the control group received chemotherapy without parenteral nutrition. The curative effects, average chemotherapy cycles, and progression-free survival were observed. The nutritional states and lymphocyte subclusters of patients were also detected. Results： The near-future curative effects of the two groups were not significantly different. However, the average chemotherapy cycle and progression-free survival of the observation group were significantly better than those of the control group. The nutritional states of the patients in the observation group were significantly better after chemotherapy, and their immune functions notably improved compared with those of the control group. Conclusion： For advanced gastric cancer patients, parenteral nutrition during chemotherapy can improve their nutrition status and immune functions, enable them more tolerant to chemotherapy and help for achieving better treatment effect.