回顾性分析单纯疱疹病毒对呼吸机相关性肺炎严重程度的影响

Retrospective analysis the influence of herpes simplex virus severity in bacterial ventilator-associated pneumonia

目的研究感染单纯疱疹病毒是否会使呼吸机相关性肺炎患者病情加重。方法收集59例符合诊断标准的呼吸机相关性肺炎(VAP)患者,按是否感染单纯疱疹病毒,分为单纯疱疹病毒(HSV)组和非单纯疱疹病毒(NHSV)组,对2组患者的相关临床资料进行比较。结果与NHSV组患者比较,HSV组患者机械通气时间明显延长(13.7±1.6)天vs(17.8±1.9)天(P<0.05),HSV组患者入住ICU时间亦明显延长(13.8±1.3)天vs(19.5±1.9)天(P<0.05);与NHSV组患者比较,HSV患者的住院时间、病死率差异均无统计学意义(26.3±3.1)天vs(30.8±3.9)天,(33.3%vs 37.5%)(均P>0.05)。结论感染单纯疱疹病毒会使呼吸机相关性肺炎患者病情加重。

Objective To explore whether herpes simplex virus（HSV） are associated with severity of bacterial ventilator-associated pneumonia（VAP）.Methods Fifty-nine patients with bacterial VAP were collected,according to whether infection with herpes simplex virus into HSV group and NHSV group,two groups of patients with relevant clinical data for comparison.Results Patients in HSV group had more ventilator days（13.7±1.6） days vs（17.8±1.9） days（P0.05）,intensive care unit days（13.8±1.3） days vs（19.5±1.9） days（P0.05） than patients in NHSV group.There is no significant difference in hospital days,mortality between HSV group and NHSV group（26.3±3.1） days vs（30.8±3.9） days,（33.3% vs 37.5%）,both P0.05.Conclusion Herpes simplex virus infect is not infrequent in VAP patients,and it is associated with greater severity.