摘要
1例55岁男性患者因急性脑梗塞、2型糖尿病及高脂血症而住院治疗。每天睡前,口服辛伐他汀40 mg。10天后,患者出现全身肌肉酸痛、肌酸激酶和转氨酶显著升高,尿色加深,尿潜血(+)。停用辛伐他汀,予补液、保肝治疗和碳酸氢钠碱化尿液治疗,16天后,全身肌肉酸痛缓解,肌酸激酶和转氨酶恢复正常,遂出院。
A 55-year-old man with acute cerebral infarction,diabetes mellitus and hyperlipidemia,who was given simvastatin 40 mg once daily at bed time for 10 days during the admitted time,he developed aching pain all over the body,and experienced dark urine and occult blood（＋）and creatine kinase and alanine transarninase level increased significantly.Simvastatin was withdrawn and the treatment of fluid infusion and hepatoprotection,sodium bicarbonate was given for 16 days,his creatine kinase level and alanine transarninase level decreased to normal,his aching pain all over the body improved markedly and then he was discharged.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2012年第1期62-63,共2页
The Chinese Journal of Clinical Pharmacology
关键词
辛伐他汀
肝损害
肌病
simvastatin
liver damage
myopathy
