贲门失弛缓症

Achalasia

贲门失弛缓症是一种病因尚未明确、累及食管平滑肌和下食管括约肌(LES)的动力障碍性疾病。以吞咽时食管体部蠕动消失、LES松弛障碍为特征,临床表现为吞咽困难和胸痛等。本病可根据临床表现结合内镜、食管钡餐造影和食管动力学检查等确诊。本文就贲门失弛缓症的流行病学现状、发病机制、临床表现和诊断相关研究进展作一概述。

Achalasia is an esophageal motility disorder with unknown etiology,involving the esophageal smooth muscle and lower esophageal sphincter（LES）,characterized by the absence of peristalsis in esophageal body and failure of LES relaxation in response to swallowing.The clinical manifestations of the disease are dysphagia and chest pain,etc,and the diagnosis can be established by clinical manifestation in combination with endoscopy,barium esophagography and manometry.This article reviewed the advances in study on current status of epidemiology,pathogenesis,clinical manifestation and diagnosis of achalasia.