原发性帕金森病患者嗅球体积测量的影像学研究

Primary olfactory bulb of Parkinson's disease imaging study of volume measurement

目的:探讨嗅球结构体积在原发性帕金森病(Parkinson's disease)和正常人的差异。方法:20列原发性帕金森病患者以及12列年龄匹配的志愿者被选入本次实验,分别对他们进行Hoehn-Yahr分级,帕金森病统一评价量表(UPDRS),左右侧肢体功能评分,简易精神状态量表(MMSE),蒙特利尔认知评估(MOCA)和磁共振成像检查。结果:正常对照组与帕金森病患者组的嗅球体积有统计学差异,帕金森病患者的嗅球体积与左右侧肢体运动功能评分、UPDRS评分、Hoehn-Yahr分级、MMSE、MOCA无明显相关性,但与患者的病程有显著相关性。结论:利用高分辨率磁共振成像计算嗅球嗅束体积能够作为帕金森病患者的早期诊断指标之一。

Objective： To investigate the difference of volume of olfactory bulb （ OB ） between Idiopathic Parkinsong disease （IPD） and the normol person. Methods：20 IPD patients and 12 age-matched controls were investigated and estimated the Hoehn-yahr degrees, UPDRS （total Unified Parkinson disease Rating Scale Scores）, MOCA, MMSE. Results：The results shows that the volume of OB is notably decreased in IPD patients in contrast of the cntrols. There is no reference between the OB volume and the degree of H-Y, MMSE, MOCA and the age. However the OB volume was related to the course of disease. Conclusion ： We conclude that the volume of the OB displayed by MRI eoulde be one of the diagnosis of the Parkinson＇s disease.