重症急性胰腺炎继发感染易感因素临床分析42例

Predisposing factors to infection secondary to severe acute pancreatitis: an analysis of 42 cases

目的:总结中西医结合治疗重症急性胰腺炎(severe acute pancreatitis,SAP)继发感染易感因素.方法:采集2000-01/2008-01天津市南开医院符合SAP标准的患者217例,统计分析符合重症急性胰腺炎继发感染的42例患者的临床资料,对临床和实验室检查20项指标进行单因素、多因素分析.结果:易感因素临床分析发现SAP患者发病至入院时间(有效治疗给予时间)、APACHE-Ⅱ评分、CT评分、PO2、肠功能恢复时间、BE六项指标继发感染与未感染差异显著(OR=2.846,7.286,34.833,0.350,24.273,0.194,均P<0.05).结论:发病至入院时间(有效治疗给予时间)、APACHE-Ⅱ评分、CT评分、PO2、肠功能恢复时间、BE是SAP继发感染的易感因素.

AIM： To conduct a systematic evaluation of predisposing factors to infection secondary to severe acute pancreatitis （SAP）. METHODS： The clinical data for 42 patients with infection secondary to SAP who were treated from January 2000 to January 2008 at Tianjin Nankai Hospital were retrospectively analyzed. Univariate and multivariate models were used to f ind predisposing factors to infection secondary to SAP. RESULTS： The interval between onset and admission （effective treatment time）, APACHE-Ⅱ score, CT score, PO2, intestinal function recovery time, and BE were signifi cantly associated with the development of secondary infection in pa-tients with SAP （OR = 2.846, 7.286, 34.833, 0.350, 24.273, 0.194, all P 0.05）. CONCLUSION： The time from onset to admis- sion, APACHE-Ⅱ score, CT score, PO2, intestinal function recovery time, and BE are predisposing factors to infection secondary to SAP.