期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

炎性体及其在流感病毒感染过程中的作用 被引量：1

Inflammasome and Its Role in the Influenza Virus Infection
原文传递
导出
摘要 炎性体是胞液中感受危险信号、启动介导下游免疫防御或细胞死亡（pyroptosis）的多分子复合物,是细胞内天然免疫的重要受承信号转导的中介体.炎性体识别流感病毒后诱导先天免疫反应甚至pyroptosis样细胞死亡.流感病毒高尔基体表达的M2蛋白和P2X7、ATP、ROS在炎性体的调节过程中发挥了重要作用,微生物也可以通过激活炎性体调节呼吸道粘膜免疫.炎性体的提出为最优疫苗的设计提供了新的思路. Inflammasome is a macromolecular protein complex, which senses intracellular danger signal, aclivates and mediates subsequent immune defense or pyroptosis, thereby functioning as a medialol： in signal transduction in innate immune system. Upon recognizing influenza virus, inflam- masome induces innate immune reaction and even pyroptosis. M2 protein that is expressed by influenza virus in the Golgi body, P2X7, ATP and ROS are important inflammasome regulalots. Mierobiota can also regulate mucous immunization of respiratory tract by activating inflammasome. The introduction of inflammasome provides a novel approach to designing optimal vaccine efficacy.
作者 陈水姣 卢放根
机构地区 中南大学湘雅二医院消化科
出处 《医学分子生物学杂志》 CAS CSCD 2011年第6期533-537,共5页 Journal of Medical Molecular Biology
关键词 炎性体 流感病毒 感染 天然免疫 inflammasome influenza virus infection innate immune
分类号 R392.11 [医药卫生—免疫学]
  • 相关文献

参考文献31

  • 1FEMANDES-ALNEMRI T,YU J W,DATTA P,et al.AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA[J].Nature,2009,458(7237):509-513.
  • 2LI H,WILLINGHAM S B,TING J P,et al.Cutting edge:inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3[J].J Immunol,2008,181(1):17-21.
  • 3EISENBARTH S C,COLEGIO O R,O'CORNNOR W,et al.Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants[J].Nature,2008,453(7198):1122-1126.
  • 4DEMENTO S L,EISENBARTH S C,FOELLMER H G,et al.Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy[J].Vaccine,2009,27(23):3013-3021.
  • 5RATHINAM V A,JIANG Z,WAGGONER S N,et al.The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses[J].Nat Immunol,2010,11(5):395-402.
  • 6ICHINOHE T,LEE H K,OGURA Y,et al.Inflammasome recognition of influenza virus is essential for adaptive immune responses[J].J Exp Med,2009,206(1):79-87.
  • 7KOMUNE N,ICHINOHE T,ITO M,et al.Measles virus V protein inhibits NLRP3 inflammasome-mediated interleukin-1β secretion[J].J Virol,2011,85(24):13019-13026.
  • 8RAJAN J V,RODRIGUEZ D,MIAO E A.The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection[J].J Virol,2011,85(9):4167-4172.
  • 9ICHINEHE T,PANG I K,IWASAKI A,et al.Influenza virus activates inflammasomes via its intracellular M2 ion channel[J].Nat Immunol,2010,11(5):404-410.
  • 10HSU L C,ALI S R,MCGILLIVRAY S,et al.A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide[J].Proc Natl Acad Sci USA,2008,105(22):7803-7808.

二级参考文献25

  • 1TSCHOPP J,MARTINON FANDBUMS K.NALPs:a novel protein family involved in inflammation[J].Nat Rev Mol Cell Biol,2003,4(2):95-104.
  • 2YAMAMOTO M,YAGINUMA K,TSUTSUI H,et al.ASC is essent-ial for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules[J].Genes Cells,2004,9(11):1055-1067.
  • 3FAUSTIN B,LARTIGUE L,BRUEY J M,et al.Reconstituted NA-LP1 inflammasome reveals two-step mechanism of caspase-1 activation[J].Mol Cell,2007,25(5):713-724.
  • 4SUN Y H,ROLAN H,GANDTSOLIS R M.Injection of flagellin into the host cell cytosol by Salmonella enterica serotype Typhimurium[J].J Biol Chem,2007,282(47):33897-33901.
  • 5FRANCHI L,EIGENBROD T,MUNOZ-PLANILLO R,et al.The inflammasome:a caspase-1-activation platform that regulates immune responses and disease pathogenesis[J].Nat Immunol,2009,10(3):241-247.
  • 6MIAO E A,ALPUCHE-ARANDA C M,DORS M,et al.Cytoplas-mic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf[J].Nat Immunol,2006,7(6):569-575.
  • 7HUBBER A,ROY C R.Modulation of host cell function by Legionella pneumophila type IV effectors[J].Annu Rev Cell Dev Biol,2010,26:261-283.
  • 8REICHARD K,JACOBS E,ROSKE I,et al.Legionella pneumophila carrying the virulence-associated lipopolysaccharide epitope possesses two functionally different LPS components[J].Microbiology,2010,156(Pt 10):2953-2961.
  • 9HALLE A,HOMUNG V,PETZOLD G C,et al.The NALP3 inflammasome is involved in the innate immune response to amyloid-beta[J].Nat Immunol,2008,9(8):857-865.
  • 10ROBERTS T L,IDRIS A,DUNN J A,et al.HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA[J].Science,2009,323(5917):1057-1060.

共引文献1

同被引文献4

引证文献1

二级引证文献3

医学分子生物学杂志
2011年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部