microRNA调控棕色脂肪细胞的分化

Regulation of Brown Adipoctye Differentiation by microRNAs

微小RNA（microRNA,miRNA）是一类长度约为20~24个核苷酸序列的内源性的具有转录后调节功能的单链非编码小RNA,在基因表达调控方面具有广泛作用,参与了生物体生长发育、细胞增殖、分化、凋亡等多种生物学过程.最新研究发现,microRNA193b-365在棕色脂肪细胞分化过程中,通过上调或下调一些影响棕色脂肪细胞分化方向的因子（如Runx1t1 、Cdon、Igfbp5、PRDM16等）的表达水平,而发挥促进棕色脂肪细胞分化的功能.促进棕色脂肪形成可增加热量的产生,同时减少脂肪堆积,从而有助于减少肥胖症及其相关疾病的发生.microRNA正性调控棕色脂肪细胞分化这一作用机制为治疗肥胖症的研究提供了新方向,有可能成为脂类代谢性疾病治疗的潜在靶点.

microRNAs （miRNAs） are endogenous non-coding single-stranded small RNA species with 20-24 nucleotides in length, miRNAs are posttranscriptional regulators of gene expression, regulating generally individual development, proliferation, differentiation and further biological processes. Recent studies have demonstrated that miRNAs play a positive role in differentiation of brown adipocytes, enhancing lipid expenditure and heat release, thus reducing the incidence of obesity and related diseases. The functional mechanism of miRNA in brown fat differentiation suggests that miRNAs may be explored as potential targets for treating obesity and lipid metabolic diseases.