单独和联合应用孟鲁司特、沙美特罗替卡松治疗成人感染后咳嗽的疗效比较

Comparison of Therapeutic Efficacies of Montelukast and Salmeterol/fluticasone Alone or Combined Use of Them in the Treatment of Adult Postinfectious Cough

目的:评价单独和联合应用孟鲁司特、沙美特罗替卡松治疗成人感染后咳嗽的疗效。方法:68例感染后咳嗽的患者(日间或夜间咳嗽症状积分在3分以上者)随机分为孟鲁司特组、沙美特罗替卡松组、孟鲁司特与沙美特罗替卡松联合治疗组(简称联合用药组),连用2周。在治疗前、治疗2周后分别记录患者的咳嗽症状积分,比较3组疗效和肺功能变化。结果:治疗2周后,孟鲁司特组、沙美特罗替卡松组、联合用药组咳嗽症状评分分别为3.67±1.72、2.79±1.50、1.81±1.01,较治疗前均有降低;治疗后3组间比较,联合用药组较孟鲁司特组、沙美特罗替卡松组差异均有统计学意义(P<0.05)。孟鲁司特组、沙美特罗替卡松组、联合用药组的有效率分别为73.9%、68.2%、87.0%,联合用药组较孟鲁司特组、沙美特罗替卡松组差异均有统计学意义(P<0.05)。3组FEV1/预计值、FEV1/FVC在治疗前、后比较及组间比较,差异均无统计学意义(P>0.05)。结论:孟鲁司特、沙美特罗替卡松对成人感染后咳嗽均有明显的疗效,并且两药联合可能具有协同作用,可为成人感染后咳嗽提供一种治疗选择。

OBJECTIVE： To evaluate the therapeutic efficacies of montelukast and salmeterol/fluticasone alone or combined use of them in the treatment of adult postinfectious cough. METHODS ： 68 adult patients with postinfectious cough （daytime and nighttime cough symptom scored 3 points or above） were randomly divided into three groups： montelukast group, salmeterol/fluticasone group and montelukast combined with salmeterol/fluticasone group （combination group）. Patients in every group received relevant medicine for 2 weeks, respectively. All patients＇ cough symptom scores were recorded before and 2 weeks later aider treatment. The therapeutic efficacy and lung function were compared among 3 groups. RESULTS： The cough symptom scores of montelukast group, salmeterol/fluticasone group and combination group were 3.67 ± 1.72, 2.79± 1.50 and 1.81± 1.01, respectively, all de- creased obviously after 2 weeks or treatment. The score of combination group was lower than that of montelukast group and salmeterol/fluticasone group （P〈0.05）. The effective rates of montelukast group, salmeterol/fluticasone group and combination group were 73.9%, 68.2%, 87.0%, respectively. There were statistical significance in different between combination group and montelukast group or salmeterol/fluticasone group （P〈0.05）. FEV1/predicted value and FEV,/FVC of 3 groups had no statistical significance before and after treatment （P〉0.05）. CONCLUSIONS： Montelukast and salmeterol/fluticasone are both effective in the treatment of adult postinfectious cough; montelukast combined with salmeterol/fluticasone can be a better choice for the treatment of adult postinfectious cough.